卷 31, 编号 1 (2025)

封面

完整期次

Clinical studies

Efficacy Evaluation of Primary Oncological Knee Arthroplasty in Patients with Tumor Involvement of the Distal Femur

Mikailov I.M., Tikhilov R.M., Grigoriev P.V.

摘要

The aim of the study was to determine the factors influencing functional outcomes and the likelihood of mechanical and infectious complications in patients with tumor involvement of the distal femur who underwent primary oncological knee arthroplasty.

Methods. We analyzed the treatment results of 227 patients who underwent primary oncological knee arthroplasty for tumor involvement of the distal femur between 2003 and 2018. Functional outcomes were assessed using the MSTS scale at the 12-month follow-up, while mechanical and infectious complications were evaluated according to the ISOLS classification. We also examined the factors affecting these outcomes.

Results. Various types of complications occurred after an average period of 70.5 months in 70 (30.8%) patients: infection (type IV) — 16 cases (7.1%); prosthesis failure (type III) — 13 (5.7%); instability of prosthetic components (type II) — 41 (18.1%). Active drainage did not affect the risk of infectious complications but significantly reduced postoperative hospital stay (p<0.001). Patients weighing more than 90 kg had a statistically significant increase in the risk of construct failure (p = 0.044). The use of rotating platform prostheses significantly reduced the risk of component failure (p = 0.016). When anatomical femoral stems and rotating platform prostheses were used, there was a significant reduction in the risks of component instability (p<0.001). The type of fixation did not increase the risk of mechanical complications (p = 0.860). Utilization of a thin cement mantle decreased the risk of prosthesis instability by 5.1 times compared to standard cementation techniques, with statistically significant differences in odds ratios. The median function of the knee joint, as measured by the MSTS scale, was 80%. Patients operated through the subvastus approach demonstrated the best joint function (p<0.001). At the 60-month follow-up, overall prosthesis survival rates ranged from 80 to 100%. However, at 125 months, the leading prostheses were Stryker (92.9%), Mutars (71.8%), and Biomet (69.1%).

Conclusions. Rotating-hinge endoprostheses showed optimal performance in reducing the risks of mechanical complications and increasing a construct lifespan. It is essential to use anatomically shaped stems when installing the femoral component. The choice of fixation method does not influence survival rate or stability of the component. It does, however, allow surgeons to take an individualized approach based on the patient’s weight, age, and bone condition. The medial subvastus approach offers the most favorable conditions for restoring knee joint function.

Traumatology and Orthopedics of Russia. 2025;31(1):5-19
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Femoral Head Reduction Osteotomy for the Treatment of Severe Femoral Head Deformities and Articular Incongruity in Children with Perthes Disease

Bortulev P.I., Baskaeva T.V., Poznovich M.S., Barsukov D.B., Pozdnikin I.Y., Rustamov A.N.

摘要

Background. Lack of adequate treatment for children with Perthes disease leads to the formation of severe femoral head deformity with articular surfaces incongruity, followed by the development of femoroacetabular impingement and early hip osteoarthritis. To date, femoral head reduction osteotomy is the most effective treatment option for such patients. However, the results of its performance have been discussed in only a few case-control studies with small sample sizes in both international and domestic literature.

The aim of the study was to evaluate the effectiveness and safety of femoral head reduction osteotomy and to analyze the further development of the hip joint in children operated for severe femoral head deformity due to Perthes disease.

Methods. We have analyzed preoperative and postoperative results of clinical and radiological examination of 20 patients (20 hip joints) aged 8 to 12 years with deformed Perthes femoral head and articular surfaces incongruity. Femoral head reduction osteotomy was performed in all patients.

Results. A radical proximal femoral reconstruction has led to significant improvement in the shape of the proximal femur with improved head sphericity and restoration of articular congruence. However, at the 6- to 12-month follow-up, some patients, primarily those with progressive lateral acetabular rim deformity, exhibited a decrease in the intraoperatively achieved Wiberg angle, an increase in the percentage of femoral head extrusion from the acetabulum, and varying degrees of Shenton line disruption.

Conclusions. Performing femoral head reduction osteotomy with correct surgical technique is an effective reconstructive technique for the treatment of children with a severe saddle-shaped deformity of the femoral head and articular surfaces incongruity. In patients with Tönnis and Sharp angles exceeding the upper limit of the physiological norm, due to the formation of secondary subluxation, it is advisable to simultaneously perform femoral head reduction osteotomy and triple/periacetabular pelvic osteotomy. This treatment option should be chosen only after a critical analysis of potential risks.

Traumatology and Orthopedics of Russia. 2025;31(1):20-33
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Revision Interventions for Failed Proximal Interphalangeal Joint Arthroplasty: Causes and Outcomes

Fedonov P., Kovalev D., Nikolaev N., Mikhailov A.

摘要

Background. In recent decades, interest in proximal interphalangeal joint (PIPJ) arthroplasty has significantly increased around the world. At the same time, a growing number of operations entail an increase in the number of reinterventions.

The aim of the study — to determine the causes and evaluate the outcomes of revision interventions for proximal interphalangeal joint arthroplasty based on the data from a federal center for trauma and orthopedics.

Methods. We analyzed gender and age distribution of patients, the number of revisions, possible causes of implant failure, its localization and type, survival rate of the construct, surgical approaches. The study covers a 15-year period.

Results. Among 95 performed primary PIPJ arthroplasties, 15 (15.8%) cases of failure were observed in 14 patients. There was 1 periprosthetic fracture; 2 cases of implant fracture; instability of implant components — 12 cases associated with injury, increased physical activity and other causative factors. The maximum failure rate was detected in the II finger (31.6% of the number of initially implanted prostheses). After primary arthroplasty, instability was most often observed in hinged implants (SBI D.G.T. PIP joint implant and the RM Finger Mathys). The option for reintervention in 2 (16.7%) cases was PIPJ arthrodesis, in 11 (83.3%) — revision arthroplasty.

Conclusions. Despite the significant (15.8%) rate of adverse outcomes after proximal interphalangeal joint arthroplasty, most frequently caused by implant instability, the survival rate of the implants reaches up to 10 years in some cases and depends both on the type of prosthesis and the patient’s occupation. Overall, revision proximal interphalangeal joint arthroplasty allows for joint mobility preservation and statistically significantly reduces pain.

Traumatology and Orthopedics of Russia. 2025;31(1):34-42
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Surgical Treatment of Chronic Infectious Cervicothoracic Spondylitis

Naumov D., Tkach S., Aliev G., Vishnevskiy A., Yablonskiy P.

摘要

Background. Chronic infectious spondylitis of the cervicothoracic spine represents an etiologically heterogeneous group of diseases characterized by vertebral destruction within the C6–T3 region. There is no common strategy for the surgical treatment of this cohort of patients.

The aim of the study was to analyze the technical features and long-term outcomes of surgical treatment for chronic infectious cervicothoracic spondylitis.

Methods. The cohort included 18 patients treated between 2018 and 2022. Considering the etiology, long-term outcomes were analyzed in 11 patients with chronic nonspecific spondylitis and 7 patients with tuberculous spondylitis. Clinical, radiological, and surgical parameters were assessed. Long-term results were evaluated at 6 and 12 months postoperatively.

Results. Chronic infectious spondylitis in the cohort was classified according to E. Pola (2017) as types B.3 (n = 10), C.2 (n = 4), C.3 (n = 1), and C.4 (n = 3). The mean age at the time of surgery was 48 years and 3 months (range 20–71). The groups were comparable in gender, age, and degree of local sagittal balance impairment. The etiology of chronic spondylitis influenced the extent of the destructive process (p = 0.009) and the severity of vertebrogenic pain syndrome (p = 0.028). Quality-of-life analysis revealed a greater degree of social maladaptation in tuberculous spondylitis group according to the NDI (p = 0.018) and SF-12 (p = 0.002) scales. Indications for various techniques of cervicothoracic reconstruction, including isolated ventral, isolated dorsal, and combined approaches, were determined.

Conclusions. Chronic infectious spondylitis of the cervicothoracic spine is a rare and poorly studied pathology. The etiology of spondylitis affects the clinical course of the disease and the incidence of postoperative complications in the long term. Analysis of available data and evaluation of the authors’ experience allowed for the development of several tactical tools for planning surgical reconstruction, including an algorithm for selecting the surgical approach and determining the need for manubriotomy. Long-term surgical outcomes using the proposed tactical algorithm confirm its effectiveness and potential for further application.

Traumatology and Orthopedics of Russia. 2025;31(1):43-54
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Computed Tomography vs Computer Modeling for Comparison and Evaluation of Anatomical Features of the Radial Head

Samokhina A., Shemyakov S., Ratiev A., Egiazaryan K.

摘要

Background. The generally accepted method of treating complex radial head fractures is arthroplasty. At the present stage, there is a variety of prosthetic designs, in production of which statistically averaged morphometric parameters are used. The anthropometric features of patients are not taken into account.

The aim of the study — to compare the morphometric parameters of the proximal radius obtained using computed tomography and computer modeling.

Methods. The study used the radiological method of examination and the computer modeling method. The study material was a database of DICOM format computer tomograms of the right and left elbow joints of 137 people (66 males, 71 females). Their age ranged from 40 to 70 years, without signs of musculoskeletal system pathology. Computer tomograms were analyzed using the RadiAnt DICOM Viewer program. Computer modeling was carried out through the ITK-SNAP program (GNU General Public License version 3.0 — GPLv3), with further processing of the obtained model using the developed software method.

Results. Comparison of the morphometric parameters of the radial head obtained using the developed computer modeling program and the morphometric parameters of a standard computed tomogram showed their identity.

Conclusion. The presented software program “Automated determination of bone morphometric parameters” will enable to model the radial head prosthesis on the basis of indicators of computer tomograms, taking into account the individual structural features of the patient’s radius.

Traumatology and Orthopedics of Russia. 2025;31(1):68-75
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Analysis of the Radiological Anatomy of the Proximal Femur after the Intramedullary Nailing of Trochanteric Fractures

Maiorov B., Belenkiy I., Sergeev G., Endovitskiy I., Sergeeva M., Isakhanyan D.

摘要

Background. Despite the high rate of the intramedullary osteosynthesis of proximal femur fractures, the incidence of implant-associated complications exceeds 50%. Poor reduction and incorrect implant positioning significantly increase the risk of mechanical complications and the frequency of unsatisfactory treatment outcomes.

The aim of the study was to evaluate various fragment positions after the intramedullary nailing of proximal femur fractures using the developed radiological criteria for assessing the quality of reduction, and to determine the association between the quality of the restoration of the proximal femur, implant position and fracture type.

Methods. In a retrospective single-center study we analyzed the primary X-rays of 108 patients with type 31A fractures. Radiological criteria were preliminarily defined. According to them, the position of the fragments and implants was considered satisfactory if the value of the neck-diaphyseal angle was more than 125°, anteversion did not exceed 20°, medial diastasis was not more than 10 mm, and there were no negative medial support, no femoral neck lengthening of more than 10 mm compared with the healthy side, and no penetration of the blade into the joint. Patients were divided into three groups according to the fracture type. We analyzed and compared the proportions of satisfactory and unsatisfactory radiological results within the groups and between them.

Results. Satisfactory reduction was noted in 83 patients (76.9%) out of 108, unsatisfactory — in 25 patients (23.1%), and 16 patients (14.8%) had incorrect implant position. Patients with type 31A1 fractures were 3.5 times less likely to have an unsatisfactory reduction than patients with type 31A2 fractures (OR 3.511; 95% CI 1.202-10.261) and 6.7 times less likely to have an unsatisfactory reduction than patients with type 31A3 fractures (OR 6.714; 95% CI 1.685-26.752). The probability of incorrect implant positioning was 6 times higher in type 31A3 fractures than in type 31A1 fractures (OR 6.000; 95% CI 1.410-25.528).

Conclusion. To improve the quality of surgical treatment, it is worth paying an increased attention to the quality of the achieved reduction, implant selection, technical peculiarities of the fixation of types A2 and A3 fractures, improvement of preoperative planning algorithms, as well as development of criteria for intraoperative radiological assessment of the quality of the restoration of the proximal femur anatomy.

Traumatology and Orthopedics of Russia. 2025;31(1):55-67
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Theoretical and experimental studies

Experimental Validation of Antimicrobial Drug Combinations for Bone Cement Impregnation

Bozhkova S., Gadzhimagomedov M., Gordina E., Antipov A., Vaganov G., Yudin V.

摘要

Background. The implantation of an antimicrobial spacer is widely used in the comprehensive treatment of periprosthetic joint infection (PJI). Most commonly, bone cement is additionally impregnated with vancomycin, which is active only against Gram-positive bacteria. However, there is a global increase in Gram-negative bacterial resistance to most antibiotics, necessitating the development of new approaches to overcome this resistance, including in the context of local antibacterial therapy.

The aim of the study was to determine the duration of antimicrobial activity and the mechanical properties of gentamicin-containing bone cement samples additionally impregnated with the combinations of highly dispersed silver (HD-Ag) and various antibiotics.

Methods. Control samples were prepared using the commercial polymethylmethacrylate-based bone cement DePuy CMW 3 Gentamicin (DePuy Synthes), which contains 4.22% gentamicin. Additionally, six experimental samples with different combinations of antimicrobial agents were prepared and tested. Antimicrobial activity (AMA) was assessed against S. aureus (MSSA, MRSA), K. pneumoniae, and P. aeruginosa. The mechanical properties of the most effective samples were evaluated in comparison with the control samples. Statistical analysis was performed using the Past 4 software system.

Results. The control samples of commercial bone cement demonstrated the shortest duration of activity against MSSA (7 days) and showed no activity against MRSA or Gram-negative bacteria. The addition of 10 wt% fosfomycin and HD-Ag to the bone cement (BC 1) tripled the AMA duration against MSSA, K. pneumoniae, and P. aeruginosa. The addition of 5 wt% vancomycin to BC 1 (BC 2) extended the AMA duration against Gram-negative bacteria to 14-16 days and against Staphylococcus spp. to 4 weeks. The highest activity against Gram-negative bacteria was observed in samples containing HD-Ag and 10 wt% aztreonam (BC 5 and BC 6), whose mechanical properties did not significantly differ from the control samples.

Conclusion. Combinations containing HD-Ag, vancomycin, fosfomycin, and aztreonam demonstrated prolonged antimicrobial activity. This may improve the effectiveness of the debridement stage in two-stage revision arthroplasty for hip periprosthetic joint infection, making these combinations promising for clinical application.

Traumatology and Orthopedics of Russia. 2025;31(1):76-84
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Morphological Assessment of Osseointegration of Titanium Implants with Ag- and Zn-Containing Calcium Phosphate Coatings

Maiborodin I., Maiborodina V., Sheplev B., Sharkeev Y., Sedelnikova M., Pavlov V., Bazlov V., Anastasieva E., Efimenko M., Kirilova I., Korytkin A.

摘要

Background. The condition of the implant surface plays an important role in extending the service life of implants and metal structures in the human body.

The aim of the study — to assess the effect of titanium implants with Ag- or Zn-containing calcium phosphate coatings on the surrounding bone tissue in experimental study.

Methods. Using light microscopy, we studied the condition of bone tissue in the proximal tibia (PT) of rabbits 4 weeks after the implantation of 3D-printed titanium cone-shaped implants with Ag- or Zn-containing calcium phosphate coating.

Results. In all cases, 3D-printed titanium implants with a rough surface integrated in the PT adhered very tightly to the bone tissue, the edges of which had minor cicatricial changes. Removal of the implants was difficult, and many tissue fragments remained on their surface. Small foreign fragments were present in the bone tissue samples examined. The sizes of foreign fragments were smaller after the use of silver ions, compared to the use of zinc ions, in both compact and cancellous bone by 84.4% (9.50±4.17 vs 17.78±7.95 μm) and 87.2% (11.21±10.68 vs 20.67±8.08 μm), respectively. In cancellous bone, the average diameter of the fragment groups and the average distance between the coating fragments or their groups were not statistically significantly different. In compact bone, they were 59.1% (155±35.98 vs 246.67±39.62 μm) and 21.2% (253.04±44.87 vs 308±50.85 μm) larger, respectively, after application of the Zn-containing coating.

Conclusions. Surface-modified titanium implants have demonstrated a tendency to osseointegration, even when the coating is damaged with the formation of foreign fragments migrating into the surrounding tissues. It is possible that modifying the technique and modes of coating application, as well as varying their thickness, will enable the full realization of the positive properties of the modified surface, including the beneficial antimicrobial characteristics of silver and zinc.

Traumatology and Orthopedics of Russia. 2025;31(1):85-97
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Case Reports

Hip Microinstability Associated with Subclinical Femoroacetabular Impingement in a Ballet Dancer: A Case Report

Gerasimov S., Morozova E.

摘要

Background. Ballet dancers have peculiarities in the morphology of the hip joints, which is determined by their professional activities. Therefore, they are more susceptible to the development of pathological conditions of joints, which often present a specific clinical picture.

The aim is to demonstrate a rare structural damage to the hip joint capsule and iliofemoral ligament in a ballet dancer.

Case description. The patient is a 32-year-old professional ballet dancer. She noted pain and limited range of motion in the right hip joint during her dance classes. Radiologic examination methods identified minimal anatomical features characteristic of femoroacetabular impingement, and damages to the acetabular labrum and structures of the anterior joint capsule. Pain and functional status were assessed using the VAS, HOOS, iHOT-12 questionnaires before surgery and at 6, 12, 18, 24, 36 and 48 months postoperatively. During the surgery, correction of bone deformity of the hip joint and all identified soft-tissue damages was successfully carried out. After 5 months, the patient returned to her professional activities. According to the VAS score, pain decreased from 6 points to 0 at the follow-up time points. At the same time a periodic slight aching pain after physical activities remained. During the follow-up, the functional status was assessed as excellent according to the HOOS and iHOT-12 questionnaires. However, the patient noted slight limitations in the range of motion when performing some professional exercises.

Conclusions. The presented clinical case demonstrates that patients with hip pain whose professional activity is associated with extreme hip range of motion require special attention during clinical provocative tests and critical evaluation of effective measurements when compared with the reference values of radiologic examination methods. In the present case, arthroscopic correction of structural damages made it possible to achieve excellent functional results through the planning and performance of surgical intervention taking into account the concept of microinstability.

Traumatology and Orthopedics of Russia. 2025;31(1):98-105
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Patient-Specific Bilateral Talus Replacement: A Case Report

Skrebtsov V., Protsko V., Skrebtsov A., Tamoev S., Kuznetsov V.

摘要

Background. Avascular necrosis of the talus predominantly affects individuals of working age. In case of bilateral pathology, determining the optimal treatment strategy remains a relevant and debatable issue.

The aim of the paper was to present the short-term outcomes of the surgical treatment of a patient with bilateral avascular necrosis of the talus using patient-specific ceramic implants.

Case description. A 32-year-old female patient presented with the complaints of bilateral ankle pain, which significantly worsened during walking. Preoperative evaluation showed the following scores: Visual Analog Scale (VAS) — 9 points, American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS AH) — 25 points, and Foot Function Index (FFI) — 139 points. The diagnosis was confirmed: avascular necrosis of the talus in both feet with bilateral grade 3 post-traumatic ankle osteoarthritis. Based on computed tomography, patient-specific talus prostheses were designed for both feet. The hemiprostheses were made of yttria-stabilized zirconia ceramic. Operations were performed with a 4-month interval: patient-specific talus replacement combined with Broström-Gould lateral ligament reconstruction on the right foot, and patient-specific talus replacement on the left foot. At follow-up 12 months after the surgery on the right foot and 8 months after the surgery on the left foot, the patient was able to walk with full weight-bearing on both lower limbs. Range of motion in both ankle joints was full, with minor pain at extreme points. Postoperative scores were as follows: VAS — 1 point, AOFAS AH — 82 points, and FFI — 28 points. The axial alignment of both ankle joints was normal, with no signs of instability. Control X-rays demonstrated the proper alignment of the ankle joints, an even joint gap, and no evidence of bone destruction.

Conclusion. The analysis of the short-term outcomes in the patient with bilateral avascular necrosis of the talus suggested that the patient-specific talus replacement was a promising treatment option. It preserved ankle joint function and lower limb weight-bearing capacity. Postoperative dynamic pedobarography revealed significant improvement in gait biomechanics.

Traumatology and Orthopedics of Russia. 2025;31(1):116-124
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Simultaneous Bilateral Fracture of the Femoral Neck in a Senile Patient: A Case Report

Belov M., Rassamakhin S., Belova K., Gordzheladze K., Vedeneev Y.

摘要

Background. Simultaneous bilateral femoral neck fracture is quite a rare injury. The literature describes single cases of such trauma occurrence as a result of low-energy exposure.

The aim is to demonstrate the choice of treatment tactics for a senile patient with simultaneous bilateral fracture of the femoral neck.

Case description. An 84-year-old patient suffered simultaneous fractures of both femoral necks as a result of a fall from a height of her own height. She was taken to the emergency department of the hospital, where the diagnosis was made based on a clinical and X-ray examination. Within 24 hours from the patient′s admission, after further examination in the department and due to the absence of concomitant pathology decompensation, single-episode sequential bilateral hip arthroplasty was performed using modular monopolar hemiprostheses. The patient was activated on the following day. At the time of discharge, on the 5th day after surgery, the patient was able to move independently using additional support. The treatment result was assessed within 3 and 12 months of follow-up and was found satisfactory. A year after the surgery, the patient moves independently, goes outside with a cane without being accompanied.

Conclusions. The described non-standard clinical case should be paid a special attention when choosing the right treatment tactics. An interdisciplinary approach and the use of minimally traumatic surgical treatment techniques to ensure timely activation of a senile patient are the priorities.

Traumatology and Orthopedics of Russia. 2025;31(1):106-115
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Modern technologies in traumatology and orthopedics

Method of Tibiocalcaneal Arthrodesis for a Total Defect of the Talus in Patients with Charcot Neuroarthropathy

Osnach S., Protsko V., Obolenskiy V., Vinogradov V., Kuznetsov V., Tamoev S.

摘要

Background. At present, treatment of patients with Charcot neuroarthropathy remains an unsolved problem. The current state of the problem motivated us to develop a new original method of hindfoot reconstruction aimed to form a tibiocalcaneal bone block with maximum possible preservation of limb length in patients with Charcot neuroarthropathy.

The aim of the paper was to demonstrate a new one-stage tibiocalcaneal arthrodesis technique aimed at preserving maximum possible limb length.

Surgical technique description. At the preoperative stage, the angle adjacent to the Gissan angle and its bisector is measured on X-rays. After performing the Kocher ankle approach with subsequent lateral malleolus resection and osteonecrectomy, the distal metaepiphysis of the tibia is cut in an oblique-horizontal plane at the bisector angle, open posteriorly and equal to the preoperatively measured value. The resulting triangular bone fragment is rotated by 180º and adapted within the external fixator.

Conclusion. The proposed method for total talar destruction in patients with Charcot neuroarthropathy is convenient and simple for adapting incongruent calcaneal and tibial surfaces and allows reducing the lower limb shortening in tibiocalcaneal arthrodesis.

Traumatology and Orthopedics of Russia. 2025;31(1):125-132
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Reviews

Feasibility of Vibration Arthrometry in Hip Arthroplasty: A Review

Tashtanov B., Rajfeld M., Vasyukov V., Pavlov V., Korytkin A.

摘要

Background. In recent years, the attention of researchers to the diagnostic method based on acoustic or vibration emission (arthrometry) has increased. The method makes it possible to detect destructive changes in the bearing components of endoprosthesis, thereby predicting their early loosening and taking appropriate preventive measures.

The aim of the review is to analyse the degree of development of vibration arthrometry methods and its role in identifying early (pre-radiological) signs of loosening of endoprosthesis components and destructive changes in them (adverse events) after hip arthroplasty.

Methods. The information was searched in eLIBRARY, PubMed, Google Scholar, and Crossref electronic databases in Russian and English. The search was performed using the following keywords: acoustic emission, vibration arthrography, vibration arthrometry, hip joint, arthroplasty. The depth of the search: from 1990 to March 2024.

Results. A total of 34 literature sources were selected. None of the studied technologies was included in the number of generally accepted medical studies, since all have significant limitations, such as dependence on the density of soft tissues surrounding the endoprosthesis, the unresolved issue of the sensors location. Also, most of the technologies have not been tested in vivo, which would show their real potential for subsequent integration into the medical system. Nevertheless, most experimental studies have demonstrated a positive result in the diagnosis of loosening, destruction of the cement mantle and endoprosthesis components.

Conclusions. The advantage of vibration arthrometry as an independent diagnostic method is that it confirms loosening of endoprosthesis components, destruction of the cement mantle and ceramics at early stages before radiographic manifestations of ongoing processes.

Traumatology and Orthopedics of Russia. 2025;31(1):133-143
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Role of Gene Polymorphisms in the Development of Aseptic Loosening of Knee and Hip Prostheses: A Review

Kamenskiy A., Don'kina A., Parakhin Y., Kovtun O., Parshikov M.

摘要

Background. Aseptic loosening is a significant issue in the endoprosthetics of major joints of the lower limbs. In the modern view, aseptic loosening of joint prostheses is primarily caused by prolonged inflammation, which induces periprosthetic osteolysis. Various factors, such as sex, age, activity level, and others, can influence the development of periprosthetic osteolysis and aseptic loosening. Some researchers attribute to the factors gene polymorphisms related to inflammation, bone metabolism, and other processes. Understanding the connection between specific genetic markers and the development of endoprosthetic complications can provide deeper insights into the mechanisms of periprosthetic osteolysis and aseptic loosening, as well as allow for better prediction of complications in patients.

The aim of the study — based on a literature review, to identify the role of individual genetic traits in the development of periprosthetic osteolysis and aseptic loosening of joint prostheses.

Methods. The search for original studies was conducted in the PubMed, Google Scholar, and eLIBRARY databases using the following keywords: endoprosthetics, genetics, aseptic loosening, polymorphism. Relevance to the research topic was verified by titles and abstracts of the articles, followed by analysis of the full-text versions. Papers with no access to the full text were not assessed.

Results. Polymorphisms in genes regulating inflammation, bone metabolism, differentiation, apoptosis, and cell division processes can influence the development of aseptic loosening. Among such genes are IL1B, IL6, RANK, OPG, FRZB, and others. Data from genome-wide association studies are contradictory and may suggest that genetic factors influencing aseptic loosening can differ among various populations.

Conclusions. Individual genetic traits might play a significant role in the development of periprosthetic osteolysis and aseptic loosening of joint prostheses. Although several studies have identified genetic polymorphisms that presumably influence the development of loosening, further research is needed to verify these results and assess the possibility of extrapolating the findings to other populations.

Traumatology and Orthopedics of Russia. 2025;31(1):144-156
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Obituaries

Viktor I. Karptsov

Traumatology and Orthopedics of Russia. 2025;31(1):157-157
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