IMPLANT-ASSOCIATED PATHOLOGY: AN ALGORITHM FOR IDENTIFYING PARTICLES IN HISTOPATHOLOGIC SYNOVIALIS/SLIM DIAGNOSTICS

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Abstract

In histopathologic SLIM diagnostic (synovial-like interface membrane, SLIM) apart from diagnosing periprosthetic infection particle identification has an important role to play. The differences in particle pathogenesis and variability of materials in endoprosthetics explain the particle heterogeneity that hampers the diagnostic identification of particles. For this reason, a histopathological particle algorithm has been developed. With minimal methodical complexity this histopathological particle algorithm offers a guide to prosthesis material-particle identification. Light microscopic-morphological as well as enzyme-histochemical characteristics and polarization-optical proporties have set and particles are defined by size (microparticles, macroparticles and supra- macroparticles) and definitely characterized in accordance with a dichotomous principle. Based on these criteria, identification and validation of the particles was carried out in 120 joint endoprosthesis pathological cases. A histopathological particle score (HPS) is proposed that summarizes the most important information for the orthopedist, material scientist and histopathologist concerning particle identification in the SLIM.

About the authors

V. Krenn

Center for Histology, Cytology and Molecular Diagnostics

Author for correspondence.
Email: krenn@patho-trier.de
Россия

P. Thomas

Hospital and Outpatients’ Clinic for Dermatology and Allergology, Ludwig Maximilian University

Email: noemail@neicon.ru
Россия

M. Thomsen

DRK Hospital, Orthopedics and Trauma Surgery

Email: noemail@neicon.ru
Россия

S. Usbeck

CeramTec GmbH

Email: noemail@neicon.ru
Россия

L. Scheuber

CeramTec GmbH

Email: noemail@neicon.ru
Россия

F. Boettner

Hospital for Special Surgery/HSS

Email: noemail@neicon.ru
Россия

W. Rüther

University Medical Center Hamburg Eppendorf

Email: noemail@neicon.ru
Россия

F. Hopf

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
Россия

S. Müller

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
Россия

M. G. Krukemeyer

Paracelsus-Kliniken Deutschland Gmbh

Email: noemail@neicon.ru
Россия

T. Gehrke

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
Россия

D. Kendoff

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
Россия

A. Tiemann

SRH Zentralklinikum Suhl, Klinik für Orthopädie und Unfallchirurgie

Email: noemail@neicon.ru
Россия

M. Huber

Institute of Pathology and Bacteriology, Otto Wagner Hospital

Email: noemail@neicon.ru
Россия

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