IMPLANT-ASSOCIATED PATHOLOGY: AN ALGORITHM FOR IDENTIFYING PARTICLES IN HISTOPATHOLOGIC SYNOVIALIS/SLIM DIAGNOSTICS

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In histopathologic SLIM diagnostic (synovial-like interface membrane, SLIM) apart from diagnosing periprosthetic infection particle identification has an important role to play. The differences in particle pathogenesis and variability of materials in endoprosthetics explain the particle heterogeneity that hampers the diagnostic identification of particles. For this reason, a histopathological particle algorithm has been developed. With minimal methodical complexity this histopathological particle algorithm offers a guide to prosthesis material-particle identification. Light microscopic-morphological as well as enzyme-histochemical characteristics and polarization-optical proporties have set and particles are defined by size (microparticles, macroparticles and supra- macroparticles) and definitely characterized in accordance with a dichotomous principle. Based on these criteria, identification and validation of the particles was carried out in 120 joint endoprosthesis pathological cases. A histopathological particle score (HPS) is proposed that summarizes the most important information for the orthopedist, material scientist and histopathologist concerning particle identification in the SLIM.

作者简介

V. Krenn

Center for Histology, Cytology and Molecular Diagnostics

编辑信件的主要联系方式.
Email: krenn@patho-trier.de
俄罗斯联邦

P. Thomas

Hospital and Outpatients’ Clinic for Dermatology and Allergology, Ludwig Maximilian University

Email: noemail@neicon.ru
俄罗斯联邦

M. Thomsen

DRK Hospital, Orthopedics and Trauma Surgery

Email: noemail@neicon.ru
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S. Usbeck

CeramTec GmbH

Email: noemail@neicon.ru
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L. Scheuber

CeramTec GmbH

Email: noemail@neicon.ru
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F. Boettner

Hospital for Special Surgery/HSS

Email: noemail@neicon.ru
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W. Rüther

University Medical Center Hamburg Eppendorf

Email: noemail@neicon.ru
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F. Hopf

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
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S. Müller

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
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M. Krukemeyer

Paracelsus-Kliniken Deutschland Gmbh

Email: noemail@neicon.ru
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T. Gehrke

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
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D. Kendoff

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
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A. Tiemann

SRH Zentralklinikum Suhl, Klinik für Orthopädie und Unfallchirurgie

Email: noemail@neicon.ru
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M. Huber

Institute of Pathology and Bacteriology, Otto Wagner Hospital

Email: noemail@neicon.ru
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