Possible prevention ways of thromboembolic events in traumatology and orthopedics: experimental study

Objective - to examine coagulative and lytic activity of blood and tissues out of a blood flow with the combined anticoagulation and antioxidant therapy in the early posttraumatic period at pelvic bone fracture. Material and methods. The study was based on estimation of coagulation activity of tissues (skeletal muscles, liver, kidneys, heart and lungs) and blood at pelvic trauma while receiving anticoagulation and antioxidant therapy. All studies were performed in accordance with the federal ethical and legal standarts of investigations in experimental animals and approved by the local ethics committee. Results. It was found that anticoagulation (fraxiparine) and antioxidant (mexidol) therapy at pelvic trauma reduce the disturbances in the hemostatic system in the early posttraumatic period. Correction of hemostatic disorders was observed not only not only in the blood (organismal level), but also in the liver, kidneys, heart, lungs (the organ level). The effect of combination therapy on skeletal muscles in the area of injury was especially important - isolated use of anticoagulation therapy did not give such significant effect. Conclusion. Thus we obtained that using anticoagulant and antioxidant therapy on pelvic trauma is pathogenetically substantiated. It affected not only the intrinsic but also on the extrinsic coagulation pathway, which significantly increased likelihood of hemostatic disorders in early posttraumatic period.

травма таза, система гемостаза, антикоагулянтная терапия, антиоксидант, pelvic trauma, hemostatic system, anticoagulation therapy, antioxidant therapy