EVALUATION OF INFLAMMATORY CHANGES IN JOINTS AT PATIENTS WITH HEMOPHILIA ACCOMPANIED RECURRENT HEMARTHROSIS
- Authors: Davydkin I.L.1, Kosyakova Y.A.1, Lartsev Y.V.1, Kapishnikov A.V.1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 18, No 2 (2012)
- Pages: 29-33
- Section: Clinical studies
- Submitted: 01.11.2016
- Published: 30.06.2012
- URL: https://journal.rniito.org/jour/article/view/240
- DOI: https://doi.org/10.21823/2311-2905-2012--2-29-33
- ID: 240
Cite item
Full Text
Abstract
Objective: to search for new diagnostic approaches for estimating the prevalence of posthemorrhagic phase of inflammation in the joints of patients with hemophilia accompanied recurrent hemarthrosis. Using the method of computerized infrared thermography measured the temperature above the knee, ankle and lower leg. Analysis of the data held with a specially developed algorithm that forms the basis of a computer program for computer (2009). It is established that with increasing temperature over the joint at high risk of recurrence monthly hemarthrosis. If the joint hemarthrosis was not, then an increase in temperature may indicate a latent flowing inflammation. Assessing the prevalence of inflammation in the joints of patients with hemophilia has prognostic value: widespread inflammation is characterized by continuous recurrent course, for a limited - monthly recurrent hemarthrosis, in the absence of inflammation in the joint, as evidenced by normal or low-grade fever, recurrent hemarthrosis are likely rare.
About the authors
I. L. Davydkin
Samara State Medical University
Author for correspondence.
Email: dagi2006@rambler.ru
Россия
Y. A. Kosyakova
Samara State Medical University
Email: Kossyyy1@yandex.ru
Россия
Y. V. Lartsev
Samara State Medical University
Email: lartcev@mail.ru
Россия
A. V. Kapishnikov
Samara State Medical University
Email: a.kapishnikov@gmail.com
Россия
References
- Воробьёв А.И. Руководство по гематологии: в 3 т. М.: Ньюдиамед; 2005. Т. 3.
- Давыдкин И.Л., Косякова Ю.А., Куртов И.В. и др. Состояние общей микроциркуляции у больных гемофилией. Вестник РУДН. 2010; 4: 197-198.
- Пат. 2428119 РФ. Способ диагностики фаз воспалительного процесса в коленных суставах у больных гемофилией. И.Л Давыдкин, Ю.А. Косякова, И.В. Куртов и др. - заявка № 2010113123 от 05.04.2010; опубл. 10.09.2011.
- Покровский В.И., Брико Н.И., ред. Общая эпидемиология с основами доказательной медицины. М.: ГЭОТАР-Медиа; 2008. 400с.
- Hoots W.K. Pathogenesis of hemophilic arthropathy. Semin. Hematol. 2006; 43 (1 Suppl. 1): S18-22.
- Hutchon D.J.R. Calculator for confidence intervals of relative risk [Internet]. Availabe from: http://www. hutchon.net/ConfidRR.htm.
- Manco-Johnson M.J., Abshire T.C., Shapiro A.D., Riske B., Hacker M.R., Kilcoyne R. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N. Engl. J. Med. 2007; 357(6): 535-544.
- Mulder K., Llinas A. The target joint. Haemophilia. 2004; 10 Suppl. 4: 152-156.
- Roosendaal G., Lafeber F.P. Pathogenesis of haemophilic arthropathy. Haemophilia. 2006; 12 Suppl. 3: 117-121.
- Van den Berg H.M., Dunn A., Fischer K., Blanchette V.S. Prevention and treatment of musculoskeletal disease in the hemophilia population: role of prophylaxis and synovectomy. Haemophilia. 2006; 12 Suppl. 3: 159-168.
- Wen F.Q., Jabbar A.A., Chen Y.X., Kazarian T., Patel D.A., Valentino L.A. c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. Blood. 2002; 100(3): 912-916.