Treatment of Periprosthetic Infection with Silver-Doped Implants Based on Two-Dimensionally Ordered Linear Chain Carbon

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Abstract

Relevance. Formation of pan-resistance microorganisms, microbial biofilms on implants and recurrent infection rate stimulate the search for optimal prosthesis materials for treatment of periprosthetic infection (PJI). Purpose of the study — to compare the efficiency of two stage PJI treatment with simultaneous implantation of a spacer in combination with implants with silver-doped coatings based on two-dimensionally ordered linear chain carbon (TDOLCC+Ag) during the first stage and the conventional revision with a spacer only. Materials and methods. The study included 72 patients with PJI of the knee (n = 42) and hip (n = 30) joints. Control group (conventional revision) consisted of 35 patients and the main group (TDOLCC+Ag coated implant incorporated in a spacer) — 37 patients. Mean age of the patients was 61 years. Temporary components were replaced by the final components during revision at the second stage. Evaluation methods: clinical, X-ray, laboratory, microbiological and follow up history. Results. Inflammation markers and synovial fluid cytosis in the groups at the first revision stage featured equal high base values. During the second stage leucocyte count and cytosis reached normal values, ESR decreased twofold in both groups, CRP decreased five times in the main group. Throat and nasal swabs demonstrated growth of Staphylococcus aureus at 24,3-32,4% in both groups. The leading inducer of PJI was staphylococcal flora with MRSA share of 7,1% and MRSE — from 62,5 to 66,7%. End-points of evaluating treatment outcomes were revision spacer implantation at the second stage of sanation and recurrent PJI. Control group featured implantation of more revision spacers (5) as compared to the main group (1) after the treatment. Two recurrent PJIs were reported for the control group in 11 months while no recurrent infection was reported for the main group. Conclusion. The study demonstrated statistically significant improvement in the outcomes of PJI treatment by spacers with implants coated by TDOLCC+Ag as compared to the conventional treatment option.

About the authors

N. S. Nikolaev

Federal Center of Traumatology, Orthopedics and Endoprosthesis Replacement;
Ulyanov Chuvash State University

Email: fake@neicon.ru
Nikolai S. Nikolaev — Dr. Sci. (Med.), Professor, Chief Physician;
Head of Department of Traumatology, Orthopedics and Emergency Medicine Russian Federation

L. V. Lyubimova

Federal Center of Traumatology, Orthopedics and Endoprosthesis Replacement

Email: fake@neicon.ru
Lyudmila V. Lyubimova — Clinical Pharmacologist Russian Federation

N. N. Pchelova

Federal Center of Traumatology, Orthopedics and Endoprosthesis Replacement

Email: fake@neicon.ru
Nadezhda N. Pchelova — Сlinical Laboratory Diagnostics Doctor Russian Federation

E. V. Preobrazhenskaya

Federal Center of Traumatology, Orthopedics and Endoprosthesis Replacement

Author for correspondence.
Email: fc@orthoscheb.com
Elena V. Preobrazhenskaya — Head of Research Department Russian Federation

A. V. Alekseeva

Federal Center of Traumatology, Orthopedics and Endoprosthesis Replacement

Email: fake@neicon.ru
Alena V. Alekseeva — Orthopedic Surgeon Russian Federation

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