Spine Tumor Epidemiology in Patients who Underwent Orthopaedic Surgery

Cover Page


Cite item

Abstract

Purpose of the study — to evaluate the frequency of spine tumors in patients who underwent orthopaedic treatment in a specialized hospital.

Materials and methods. Ап patients treated in the Vreden Russian Research Institute of Traumatology and orthopedics (rniito) with spine tumor diagnosis were examined from 2000 till 2017. The data was obtained from medical histories. Patients’ distribution per gender, age, histological type and tumor location was evaluated.

Results. 2023 patients were included into the study, where 1298 (64.3%) were female. Patients with secondary metastases prevailed (59% overall), including breast cancer (43.6%), renal carcinoma (18%) and lung cancer (10.7%). Among benign tumors (overall 18.7%) symptomatic hemangiomas prevailed (93.8%). Primary malignant tumors (total 10.2%) were represented mainly by multiple myeloma (54.2%) and plasmacytoma (14.6%). Intermediate tumors with local aggressive growth were observed rarely (overall 3.9%).

Conclusion. Spine is affected mainly by secondary tumors, where metastases of breast, renal and lung cancer are observed most often. Benign symptomatic hemangiomas demonstrate a high prevalence. Primary malignant tumors are presented mainly by multiple myeloma. Other primary malignant tumors and tumors with local aggressive growth are observed rather rarely.

About the authors

N. S. Zaborovsky

Vreden Russian Research Institute of Traumatology and Orthopedics

Author for correspondence.
Email: n.zaborovskii@yandex.ru

Nikita S. Zaborovskii — Cand. Sci. (Med.), research fellow, Spine Surgery and oncology Department.

St. Petersburg

Russian Federation

D. A. Ptashnikov

Vreden Russian Research Institute of Traumatology and Orthopedics; Mechnikov North-Western State Medical University

Email: fake@neicon.ru

Dmitrii A. Ptashnikov — Dr. Sci. (Med.), professor, head of Spine Surgery and oncology Department, Vreden RRITO; head of Traumatology and orthopedics Department, Mechnikov NWSMU.

St. Petersburg

Russian Federation

E. E. Topuzov

Mechnikov North-Western State Medical University; St.Petersburg Municipal Clinical Oncology Dispensary

Email: fake@neicon.ru

Eldar E. Topuzov — Dr. Sci. (Med.), professor, chief physician, St. Petersburg city clinical oncology center; head of Hospital Surgery Department, Mechnikov NWSMU.

St. Petersburg

Russian Federation

E. V. Levchenko

Petrov National Medical Research Center for Oncology

Email: fake@neicon.ru

Evgeny V. Levchenko — Dr. Sci. (Med.), head of the Surgical Thoracic Department, Head of the Scientific Department of Thoracic oncology.

St. Petersburg

Russian Federation

D. A. Mikhailov

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Dmitrii A. Mikhaylov — cand. Sci. (Med.), research fellow, Spine Surgery and oncology Department, Vreden Russian Research Institute of Traumatology and orthopedics, St. Petersburg, Russian federation

Russian Federation

K. E. Natalenko

Sokolov Clinical Hospital No.122

Email: fake@neicon.ru

Kirill E. Natalenko — orthopedic surgeon, oncology Department.

St. Petersburg

Russian Federation

References

  1. Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2017 г. (заболеваемость и смертность). М., 2018. С. 4-6.
  2. Perrin R.G., Laxton A.W. Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients. Neurosurg Clin N Am. 2004;15(4):365-373.
  3. Unni K.K., Inwards C.Y. Mayo Foundation for Medical Education and Research. Dahlin’s bone tumors : general aspects and data on 10,165 cases. Wollters Kluwer Health/Lippincott Williams & Wilkins, 2010. 402 p.
  4. Coleman R.E. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12(20 Pt 2):6243s-6249s.
  5. Sciubba D.M., Petteys R.J., Dekutoski M.B., Fisher C.G., Fehlings M.G., Ondra S.L. et al. Diagnosis and management of metastatic spine disease. A review. J Neurosurg Spine. 2010;13(1):94-108. doi: 10.3171/2010.3.SPINE09202.
  6. Abrahm J.L., Banffy M.B., Harris M.B. Spinal cord compression in patients with advanced metastatic cancer: «all I care about is walking and living my life». JAMA. 2008;299(8):937-946. doi: 10.1001/jama.299.8.937.
  7. Chi J.H., Bydon A., Hsieh P., Witham T., Wolinsky J.P., Gokaslan Z.L. Epidemiology and demographics for primary vertebral tumors. Neurosurg Clin N Am. 2008;19(1):1-4.
  8. Kelley S.P., Ashford R.U., Rao A.S., Dickson R.A. Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J. 2007;16(3):405-409. doi: 10.1007/s00586-006-0188-7.
  9. Мушкин А.Ю., Мальченко О. Онкологическая вертеб-рология: избранные вопросы. Новосибирск, 2012. С. 8.
  10. Bucholtz J.D. Metastatic epidural spinal cord compression. Semin Oncol Nurs. 15(3):150-159. doi: 10.1016/S0749-2081(99)80002-3.
  11. Fourney D.R., Gokaslan Z.L. Spinal instability and deformity due to neoplastic conditions. Neurosurg Focus. 2003;14(1):e8.
  12. Bilsky M.H., Laufer I., Burch S. Shifting paradigms in the treatment of metastatic spine disease. Spine (Phila Pa 1976). 2009;34(22 Suppl):S101-107. doi: 10.1097/BRS.0b013e3181bac4b2.
  13. Sterling J.A., Edwards J.R., Martin T.J., Mundy G.R. Advances in the biology of bone metastasis: how the skeleton affects tumor behavior. Bone. 2011;48(1):6-15. doi: 10.1016/j.bone.2010.07.015.
  14. Boriani S., Weinstein J.N., Biagini R. Primary bone tumors of the spine. Terminology and surgical staging. Spine (Phila Pa 1976). 1997;22(9):1036-1044.
  15. Ropper A.E., Cahill K.S., Hanna J.W., Mccarthy E.F., Gokaslan Z.L., Chi J.H. Primary vertebral tumors: a review of epidemiologic, histological, and imaging findings, Part I: benign tumors. Neurosurgery. 2011;69(6):1171-1180. doi: 10.1227/NEU.0b013e31822b8107.
  16. Ropper A.E., Cahill K.S., Hanna J.W., Mccarthy E.F., Gokaslan Z.L., Chi J.H. Primary vertebral tumors: a review of epidemiologic, histological and imaging findings, part II: locally aggressive and malignant tumors. Neurosurgery. 2012;70(1):211-219; discussion 219. doi: 10.1227/NEU.0b013e31822d5f17.
  17. Sundaresan N., Rosen G., Boriani S. Primary malignant tumors of the spine. Orthop Clin North Am. 2009;40(1):21-36. doi: 10.1016/j.ocl.2008.10.004.
  18. Slon V., Stein D., Cohen H., Sella-Tunis T., May H., Hershkovitz I. Vertebral hemangiomas: their demographical characteristics, location along the spine and position within the vertebral body. Eur Spine J. 2015;24(10):2189-2195. doi: 10.1007/s00586-015-4022-y.
  19. Fisher C.G., Saravanja D.D., Dvorak M.F., Rampersaud Y.R., Clarkson P.W., Hurlbert J. Et al. Surgical management of primary bone tumors of the spine: validation of an approach to enhance cure and reduce local recurrence. Spine (Phila Pa 1976). 2011;36(10):830-836. doi: 10.1097/BRS.0b013e3181e502e5.
  20. Kelley S.P., Ashford R.U., Rao A.S., Dickson R.A. Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J. 2007;16(3):405-409.
  21. Cole J.S., Patchell R.A. Metastatic epidural spinal cord compression. Lancet Neurol. 2008;7(5):459-466. doi: 10.1016/S1474-4422(08)70089-9.
  22. Prasad D., Schiff D. Malignant spinal-cord compression. Lancet Oncol. 2005;6(1):15-24. doi: 10.1016/S1470-2045(04)01709-7.
  23. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7-30. doi: 10.3322/caac.21442.
  24. Coleman R.E. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931.
  25. Беляев А.М., Гафтон Г.И., Киреева Г.С., Сенчик К.Ю., Гусейнов К.Д., Левченко Е.В. и др. Новые подходы к лечению злокачественных новообразований с использованием перфузионных технологий. Вопросы онкологии. 2016;(2):2М-220.
  26. Chetty I.J., Martel M.K., Jaffray D.A., Benedict S.H., Hahn S.M., Berbeco R. Et al. Technology for Innovation in Radiation oncology. Int J Radiat Oncol Biol Phys. 2015;93(3):485-492. doi: 10.1016/j.ijrobp.2015.07.007.
  27. Schnipper L.E., Davidson N.E., Wollins D.S., Tyne C., Blayney D.W., Blum D. Et al. American society of clinical oncology statement: a conceptual framework to assess the value of cancer treatment options. J Clin Oncol. 2015;33(23):2563-2577. doi: 10.1200/jco.2015.61.6706.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies