ALLOGENEIC BONE GRAFTING MATERIALS – UPDATE OF THE CURRENT SCIENTIFIC STATUS

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Worldwide population aging and associated with it epidemics of osteoporosis, widespread of bone and joint reconstructive surgery and first of all joint replacement lead to explosive growth of interest in bone grafting.

Although autografts are still the golden standard in bone regeneration, allogeneic bone substitutes have reached a state that allows for their application with satisfying clinical results. However, it has repeatedly been supposed that the different allogeneic materials underwent different purification processes, which modifies bone regeneration properties of these materials and also for different safety conditions. In the present publication, the treatment of the precursor tissue, the safety conditions, and the regenerative possibilities of C+TBA bone blocks based in preclinical and clinical data are described. Thus, it is described how the risks of infections and also immunological reactions becomes completely eliminated, while the special purification process allows for preservation of the native structure of the bone block. Both the in vitro studies and the clinical trials including histological follow-ups showed the optimal regeneration properties of these bone blocks. It has been shown that the allogeneic bone grafts have been integrated without causing inflammatory anomalies at the implantation site. Altogether, the allogeneic bone substitute material serves as an excellent basis for the formation of new bone. Finally, the combination of the allogeneic C+TBA bone blocks with different antibiotics is described. Interestingly, it is possible to combine the allogeneic bone substitute ether with antibiotics in the sense of prophylaxis and/or with bone marrow aspirate in order to accelerate bone remodeling.

作者简介

R. Schnettler

University Medical Center, Justus Liebig University of Giessen

编辑信件的主要联系方式.
Email: Reinhard.Schnettler@chiru.med.uni-giessen.de

Reinhard Schnettler — MD, professor, the Head of the Trauma Surgery Department.

Klinikstrasse, 29, D-35392 Giessen

德国

J. Franke

Elbe Klinikum

Email: fake@neicon.ru

Jorg Franke — MD, the Head of the Department of Trauma and Orthopaedic Surgery, Elbe Klinikum Stade Unfallchirurgie und Orthopädie.

Stade 德国

D. Rimashevskiy

Peoples› Friendship University of Russia

Email: fake@neicon.ru

Dmitry Rimashevskiy — Cand. Sci. (Med.) Associate Professor, Traumatology and Orthopedics Department.

Moscow

俄罗斯联邦

N. Zagorodniy

Peoples› Friendship University of Russia

Email: fake@neicon.ru

MoscowNikolai V. Zagorodniy — Dr. Sci. (Med.), professor, the Head of Traumatology and Orthopedics Department.

Moscow 俄罗斯联邦

N. Batpenov

Scientific Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Nurlan Batpenov — MD, Dr. Sci. (Med.), professor, director.

Astana 哈萨克斯坦

R. Unger

Institute of Pathology, Johannes Gutenberg University

Email: fake@neicon.ru

Ronald E. Unger — MD.

Mainz 德国

S. Wenisch

Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University of Giessen

Email: fake@neicon.ru

Sabina Wenisch — MD, Professor.

Giessen

德国

M. Barbeck

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin; Botiss Biomaterials

Email: fake@neicon.ru

Mike Barbeck — MD, Senior Researcher.

Berlin 德国

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