Neuroendocrinal regulation of bone metabolism in osteoarthritis of large joints (review)

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The regulation of bone metabolism by adrenergic, cholinergic and endocrine transmitters in osteoarthritis is reviewed. Regulatory effects of α- and β-receptor mechanisms of norepinephrine, M- and N-receptors of acetylcholine, glucocorticosteroids, PTH and peptidergic systems in the bone remodeling process are characterized that can serve as a basis for the development of promising therapies osteoarthritis.

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A. Lychkova

Moscow Clinical Research Center of Moscow Health Department

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L. Shirokova

Yaroslavl State Medical University

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E. Kryukova

Yaroslavl State Medical University; Vologda Regional Clinic Hospital

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