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Acetylsalicylic acid administration for pharmaceutical prophylaxis of thromboembolic complications is a highly controversial and debatable issue. Debates continue, and, in particularly, opposite views of ACCP recommendations (8th and 9th revisions), Russian clinical recommendations and AAOS guideline were discussed during the Vreden’s Readings conference in 2017 and motivated the authors to compile the present analytical review. The authors attempted to explain initial ban for use and later on sudden advisable use of acetylsalicylic acid for thromboembolism prophylaxis. There can be no unique answer to such a problem due to ambiguity of current state of evidence-based medicine and current system for defining the clinical guidelines.

About the authors

A. P. Sereda

Federal Medical Biological Agency

Author for correspondence.

Dr. Sci. (Med), Deputy Head

30, Volokolamskoye shosse, 23182, Moscow

Russian Federation


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