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Purpose - evaluation of the effectiveness of debridement in the treatment of periprosthetic infection and detection of possible factors affecting the outcome. Material and methods: Analysis of the effectiveness of treatment in 125 patients with periprosthetic infection operated at Vreden Russian Research Institute of Traumatology and Orthopedics in 2008-2012 was carried out. All patients underwent endoprosthesis-saving sanitation surgery at different times. The effectiveness of surgery was evaluated using clinical, X-ray, laboratory, and statistical methods. To estimate a subjective component, Harris and visual analog scales were used. Results: Recurrent infections after sanitation surgery were detected in 20 (15.7%) patients (Group 1). 105 (84%) patients in the follow-up of above 12 months demonstrated remission of infectious process (Group 2). Cardiovascular pathology and obesity were significantly more common in Group 1 patients (р<0.01). In 63% patients of Group 2 sanitation operation was performed within a month after primary arthroplasty, whereas in patients with relapses this figure was only 25% (р<0.01).Gram-positive bacteria dominated in the spectrum of pathogens of periprosthetic infection in both study groups, however, S. epidermidis was somewhat more common in the group with relapses. Conclusion: The time of sanitation surgery, cardiovascular diseases and bacterial species are the main risk factors leading to recurrent infections.

About the authors

B. Lyu

Vreden Russian Research Institute of Traumatology and Orthopedics

Author for correspondence.
Email: info@rniito.ru
Russian Federation

R. M. Tikhilov

Vreden Russian Research Institute of Traumatology and Orthopedics; Mechnikov Northwestern State Medical University

Email: info@rniito.org
Russian Federation

I. I. Shubnyakov

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: shubnyakov@mail.ru
Russian Federation

S. A. Bozhkova

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: clinpharm-rniito@yandex.ru
Russian Federation

V. A. Artyukh

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: artyukhva@mail.ru
Russian Federation

A. O. Denisov

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: med-03@yandex.ru
Russian Federation


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