EXPERIMENTAL ESTIMATION OF COMPOSITE MATERIAL CONTAINING THE PROTEIN-MINERAL COMPONENTS AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 AS A COVERING OF TITANIUM IMPLANTS

M. Z. Fedorova; Федорова М. З.; S. V. Nadezhdin; Надеждин С. В.; A. S. Semikhin; Семихин А. С.; M. A. Lazebnaya; Лазебная М. А.; G. V. Khramov; Храмов Г. В.; Y. R. Kolobov; Колобов Ю. Р.; A. V. Gromov; Громов А. В.; M. S. Bartov; Бартов М. С.; V. G. Lunin; Лунин В. Г.; A. S. Karyagina; Карягина А. С.; D. V. Gunderov; Гундеров Д. В.

doi:10.21823/2311-2905-2011-0-2-101-106

EXPERIMENTAL ESTIMATION OF COMPOSITE MATERIAL CONTAINING THE PROTEIN-MINERAL COMPONENTS AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 AS A COVERING OF TITANIUM IMPLANTS

Authors: Fedorova M.Z.¹, Nadezhdin S.V.¹, Semikhin A.S.², Lazebnaya M.A.¹, Khramov G.V.¹, Kolobov Y.R.¹, Gromov A.V.², Bartov M.S.², Lunin V.G.², Karyagina A.S.², Gunderov D.V.³
Affiliations:
1. ГОУ ВПО «Белгородский государственный университет»
2. ГУ НИИ «Эпидемиологии и микробиологии им. Н.Ф. Гамалеи» РАМН
3. Уфимский государственный авиационно-технический университет
Issue: Vol 17, No 2 (2011)
Pages: 101-106
Section: Theoretical and experimental studies
Submitted: 07.11.2016
Accepted: 07.11.2016
Published: 30.06.2011
URL: https://journal.rniito.org/jour/article/view/430
DOI: https://doi.org/10.21823/2311-2905-2011-0-2-101-106
ID: 430

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Abstract

The influence of both, the composite material based on the protein-mineral components including the prolonged form of the recombinant human bone morphogenetic protein 2 (rhBMP-2) and the method of the titanium implant’s surface treatment, on the reparative osteogenesis and adhesion strength of the bone tissue – implant’s surface contact was evaluated. Covering of implants with the composite coating promotes significant acceleration of the bone tissue regeneration processes in the site of implants loading. The composition coating with prolonged form of the rhBMP-2 promoted increasing of the neogenic bone tissue’s adhesion with the implants, as compared with the coating without recombinant human bone morphogenetic protein. The implants treated with microarc oxidation demonstrated higher values of the breakout force during the separation of the implants from the bone than the implants treated with sandblasting method.

Keywords

titanium implant, recombinant bone morphogenetic human protein-2

About the authors

M. Z. Fedorova

ГОУ ВПО «Белгородский государственный университет»

Email: fake@neicon.ru

д.б.н., профессор, старший научный сотрудник НОиИЦ «Наноструктурные материалы и нанотехнологии»

Украина

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EXPERIMENTAL ESTIMATION OF COMPOSITE MATERIAL CONTAINING THE PROTEIN-MINERAL COMPONENTS AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 AS A COVERING OF TITANIUM IMPLANTS

Full Text

Abstract

Keywords

About the authors

References

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