Knee degenerative osteoarthritis secondary to ochronosis (case report)

Cover Page


Cite item

Full Text

Abstract

Alkaptonuria is rare disease with deficiency of homogentisate-1,2-dioxygenase enzyme, resulting in excess deposition of homogentisic acid in connective tissue. This deposition leads to ochronosis - brownish-black pigmentation of connective tissue. The result of pigmentation is weakness of connective tissue and, finally, chronic inflammation and osteoarthtritis. Currently specific treatment is absent, only sympothomatic. But total knee arthroplasty has good outcomes in patients of severe ochronotic arthritis similar to osteoarthritic patients without ochronosis. We present a case report of a patient with knee ochronotic arthritis treated with total knee arthroplasty.

About the authors

V. V. Bliznyukov

Vreden Russian Research Institute of Traumatology and Orthopedics

Author for correspondence.
Email: info@rniito.org
Россия

A. N. Kovalenko

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: tonnchik@ya.ru
Россия

V. P. Rumakin

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: v_rumakin@mail.ru
Россия

References

  1. Abimbola O., Hall G., Zuckerman J.D. Degenerative arthritis of the knee secondary to ochronosis. Bull NYU Hosp. Jt. Dis. 2011;69(4):331-334.
  2. Albers S.E., Brozena S.J., Glass L.F., Fenske N.A. Alkaptonuria and ochronosis: case report and review. J Am Acad Dermatol. 1992;27(4):609-614.
  3. Borman P., Bodur H., Ciliz D. Ochronotic arthropathy. Rheumatol Int. 2002;21(5):205-209.
  4. Gaines J.J. Jr. The pathology of alkaptonuric ochronosis. Hum. Pathol. 1989; 20(1):40-46.
  5. Farzannia A., Shokouhi G., Hadidchi S. Alkaptonuria and lumbar disc herniation. Report of three cases. J. Neurosurg. 2003; 98(1 Suppl):87-89.
  6. Fernández-Cañón J.M., Granadino B., Beltrán-Valero de Bernabé D. et al. The molecular basis of alkaptonuria. Nat Genet. 1996;14(1):19-24.
  7. Kefeli M., Tomak Y., Can B., Bariş S. Arthroplasty for the treatment of joint degeneration caused by ochronosis in two cases. Acta Orthop. Traumatol. Turc. 2008;42(2):139-144.
  8. Kerimoglu S., Onder C., Aynaci O., Malkoc C.H. Hip arthroplasty for ochronosis. Saudi Med. J. 2005;26(11):1812-1814.
  9. La Du B.N. Jr. Alcaptonuria and ochronotic arthritis. Mol. Biol. Med. 1991;8(1):31-38.
  10. Laskar F.H., Sargison K.D. Ochronotic arthropathy. A review with four case reports. J. Bone Joint Surg. Br. 1970;52(4):653-666.
  11. Mannoni A., Selvi E., Lorenzini S. et al. Alkaptonuria, ochronosis, and ochronotic arthropathy. Semin. Arthritis Rheum. 2004;33(4):239-248.
  12. Nas K., Gür A., Akdeniz S. et al. Ochronosis: a case of severe ochronotic arthropathy. Clin Rheumatol. 2002; 21(2):170-172.
  13. O‘Brien W., La Du B.N., Bunim J.J. Biochemical, pathologic and clinical aspects of alcaptonuria, ochronosis, and ochronotic arthropathy. Am. J. Med. 1963;34:813-838.
  14. Selvi E., Manganelli S., Mannoni A. et al. Chronic ochronotic arthritis: clinical, arthroscopic, and pathologic findings. J. Rheumatol. 2000;27(9):2272-2274.
  15. Spencer J.M., Gibbons C.L., Sharp R.J. et al. Arthroplasty for ochronotic arthritis: no failure of 11 replacements in 3 patients followed 6-12 years. Acta Orthop. Scand. 2004;75(3):355-358.
  16. Philippot R., Coste C., Lasseur E., Tramond P., Rollier J.C., Moyen B. Ochronosis or black cartilage disease. Rev. Chir. Orthop. 2008; 94(7):693-696.
  17. Wauthy P., Seghers V., Mathonet P., Deuvaert F.E. Cardiac ochronosis: not so benign. Eur. J. Cardiothorac. Surg. 2009;35(4):732-733.
  18. Zatková A., de Bernabé D.B., Poláková H. et al. High frequency of alkaptonuria in Slovakia: evidence for the appearance of multiple mutations in HGO involving different mutational hotspots. Am. J. Hum. Genet. 2000;67(5):1333-1339.
  19. Zhao B.H., Chen B.C., Shao de C., Zhang Q. Osteoarthritis? Ochronotic arthritis! A case study and review of the literature. Knee Surg. Sports Traumatol. Arthrosc. 2009;17(7):778-781.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 82474 от 10.12.2021.