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Vliyanie D,L-karnitina na regeneratsiyuperifericheskogo nerva pri ego polnom pereryve
- Authors: Seryakov V.I.1
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Affiliations:
- Issue: No 4 (2008)
- Pages: 15-20
- Section: ARTICLES
- Submitted: 19.07.2022
- Published: 15.12.2008
- URL: https://journal.rniito.org/jour/article/view/1898
- DOI: https://doi.org/10.17816/2311-2905-1898
- ID: 1898
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Abstract
The aim of the work - to study the influence of impulsive magnetic field and D,L-carnitine on the processes of peripheric nerve degeneration and regeneration after the carrying-out of epiperineural suture. 30 rabbits - the males of the breed "chinchilla", which were assigned to 3 groups, were operated. 10% solution of D,L-carnitine was daily introduced to III group during 10 days after the operation into ear vein in dose 30 mgДg diluted with physiologic saline. Carnitine as many other biomolecules thanks to the presence of asymmetrical C-atom in their structure in β-position may be in two isomeric forms that have equal chemical composition but different spatial configuration and each configuration is the mirror reflection of another one - L-carnitine (left form) and D-carnitine (right form), this difference leads to their absolutely different value for human organism. D,L-carnitine stimulates not only the utilization of decayed axons and myelinic membranes but the regeneration of the nerve fibers of anatomically restored peripheric nerve, greatly reduces the area of neurotrophic ulcers, hastens their healing.
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References
- Ефимова, Е.В. Ацетил-L-карнитин: биологические свойства и клиническое применение / Е.В. Ефимова, Т.А. Гуськова, В.М. Копелевич, В.И. Гунар // Химико-фармацевтический журнал. - 2002. - Т. 36, № 3. - С. 3-7.
- Кузин, В. М. Карнитина хлорид (25 лет в клинической практике) / В.М. Кузин // Русский медицинский журнал. - 2003. - Т. 11, № 10. - С. 5-9.
- Спасов, А.А. Стереофармакологические особенности карнитина / АА. Спасов, И.Н. Иежица // Российский физиологический журнал им. И.М. Сеченова. - 2005. - Т. 91, № 12. - С. 1469-1480.
- DeGrandis, D. L-acetylcarnitine in the treatment of patients with peripheral neuropathies / D. DeGrandis, L. Santoro, P. DiBenedetto // Clin. Drug Invest. - 1995. - N 10. - P. 317-322.
- De Grandis, D. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study / D. De Grandis, C. Minardi // Drugs R D. - 2002. - Vol. 3, N 4. - P. 223-31.
- Fu, S.Y. The cellular and molecular basis of peripheral nerve regeneration / S.Y. Fu, T. Gordon // Mol. Neurobiol. - 1997. - N 14. - P. 67-116.
- Hall, S.M. Nerve repair: a neurobiologist's view / S.M. Hall // J. Hand Surg. - 2001. - Vol. 26-B. - P. 129-136.
- Lunborg, G. 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance / G. Lunborg // J. Hand Surg. - 2000. - Vol. 25A - P. 391-414.
- Tempesta, J.L. A pharmacological profile of the effects of camitine and acetylcamitine on the central nervous system /J.L. Tempesta // Int. J. Clin. Pharm. Res. -1983. - N 3. - P. 295-306.
- Terenghi, G. Peripheral nerve regeneration and neurotrophic factors / G. Terenghi // J. Anat. - 1999. - Vol. 194.-P. 1-14.
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