FEATURES OF IMMUNE STATUS IN ADOLESCENTS WITH COXARTHROSIS

Cover Page


Cite item

Full Text

Abstract

Purpose: To Study immune status in patients with coxarthrosis consequent to treatment of congenital hip dysplasia and Perthes' disease as well as to determine additional variables indicating arthrosis progression.

Materials and methods: The authors analyzed results of preoperative immune examination of 13 male patients aged 11,4±0,7 years (10-13) with coxarthrosis of type I-II developed consequently to treatment of hip dysplasia and Perthes' disease. Based on obtained anatomical and functional outcomes the authors divided the patients into two groups. First group included 8 patients with postoperative improvement of joint function and absence of disease progression. Second group (5 patients) was featured by functional deterioration and arthrosis advancing.

Results: Patients of the second group demonstrated statistically significant elevation in certain parameters of humoral (circulating immune complex) and cellular immunity (CD3+HLA-DR (%), CD3+HLA-DR (109/l)) as well as interleukin-6.

Conclusion: Obtained results have proven that initial immune parameters (IL-6, circulating immune complex, lymphocytes with activation markers) can be used as additional variables for decision making in regard to option and advisability of reconstructive joint preserving procedures in patients with coxarthrosis consequent to treatment of hip dysplasia and Perthes' disease.

About the authors

M. V. Chepeleva

Ilizarov Russian Scientific Center «Restorative Traumatology and Orthopedics», Kurgan

Email: fake@neicon.ru

Chepeleva Marina V. - senior researcher, laboratory of clinical microbiology and immunology

Russian Federation

M. P. Teplenky

Ilizarov Russian Scientific Center «Restorative Traumatology and Orthopedics», Kurgan

Author for correspondence.
Email: TeplenkiyMp@mail.ru

Teplenky Mikhail P. - head of the laboratory of pathology of the join.

Ul. M. Ulyanova, 6, Kurgan, Russia, 640014, e-mail: TeplenkiyMP@mail.ru

Russian Federation

References

  1. Балабанова Р.М. Роль иммунного воспаления в патогенезе остеоартроза, возможности коррекции иммунных нарушений. Современная ревматология. 2011;(4):47-78.
  2. Дмитриева Л.А Роль цитокинов в патогенезе остеоартроза. Бюлл. ВСНЦ СО РАМН. 2007;(4):165-169.
  3. Копылова Д. А., Остапенко В. А. Связь клинических проявлений остеоартроза с изменением уровня интер-лейкина 6 в крови. Научно-практическая ревматология. 2012;(5):34-36.
  4. Цурко В.В. Малышева Н.В. Иванова Т.Б. Егоров И.В. патобиология суставного синдрома. ЬШВп в современной практике. Справочник поликлинического врача. 2011;(1):59-61.
  5. Чепелева М.В., Клюшин Н.М., Ермаков А.М., Абабков Ю.В. Интерлейкин-6 в прогнозировании течения послеоперационного периода у пациентов с перипротез-ной инфекцией тазобедренного сустава. Сибирский научный медицинский журнал. 2015; 35(4):45-48.
  6. Чепелева М.В., Тёпленький М.п. Влияние возрастного фактора на иммунный статус детей и подростков с диспластической патологией тазобедренного сус_ тава в процессе хирургического лечения методом чрескостного остеосинтеза. Педиатрия. Журнал имени Г.Н. Сперанского. 2015;94(4):93-98.
  7. Чепелева М.В., Швед Н.С. Иммунологические особенности остеоартроза крупных суставов различной этиологии. Гений ортопедии. 2012;(2):107-111.
  8. Шевченко Н.С., Лебец И.С., Нелина И.Н., Кашкалда Д.А., Матвиенко Е.В., Летяго А.В. патогенетическая значимость воспаления при остеоартрозе у подростков с инициальными суставными заболеваниями. Украинский ревматологический журнал. 2010;39(1): 50-54.
  9. D'Aubigne R.M., Postel M. Function al results of hip arthroplasty with acrylic prosthesis. J Bone Joint Surg Am. 1954;36:451-475.
  10. De Kleuver M, Kooijman MA, Pavlov PW, Veth RP. Triple osteotomy of the pelvis for acetabular dysplasia. J BoneJoint Surg Br. 1997; 79(2): 225-229.
  11. Haverkamp D., Marti R.K. Intertrochanteric osteotomy combined with acetabular shelfplasty in young patients with severe deformity of the femoral head and secondary osteoarthritis. A long-term follow-up study. J Bone Joint Surg Br. 2005;87(1):25-31.
  12. Janssen D. Kalchschmidt K., Katthagen B.D. Triple pelvic osteotomy as treatment for osteoarthritis secondary to developmental dysplasia of the hip. Intern Orthop. 2009; 33(6):1555-1559. doi: 10.1007/s00264-008-0718-5.
  13. Leitz G., Reck R. Necessarily Disappointing Results After Trippleosteotomy in the Dysplastic Hip Joint. Arch Orthop Traumat Surg. 1979;(95):271-273.
  14. Livshits G., Zhai G., Hart D.J. et al. Interleukin-6 is a significant predictor of radiographic knee osteo-arthritis: The Chingford Study. Arthritis Rheum. 2009;60(7):2037-2045.
  15. Lotz M. Cytokines in cartilage injury and repair. Clin Orthop. 2001;(391):108-115.
  16. Millis M.B., Murphy S.B., Poss R. Osteotomies about the hip for the prevention and treatment of osteoarthrosis. Instr Course Lect. 1996;(45):209-26.
  17. Nacamura S., Ninomiya S., Takatori Y. et al. Long-term outcome of rotational acetabular osteotomy. Acta Orthop Scand. 1998;69(3):259-265.
  18. Severin E. Contribution to the knowledge of congenital dislocation of the hip joints: late results of closed reduction and arthrographic studies of recent cases. Acta Chir Scand Suppl. 1941;84:1-142.
  19. Stannus O., Jones G., Cicuttini F. et al. Circulating levels of IL-6 and TNF-a are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 2010;18(11):1441-1447.
  20. Tonnis D., Arning A., Bloch M. et al. Triple pelvic osteotomy. JPediatr Orthop Part Br. 1994;3(1):54-67.
  21. Trousdale R.T., Ekkernkamp A., Ganz R. et al. Periacetabular and Intertrochanteric Osteotomy for the Treatment of Osteoarthrosis in Dysplastic Hips. J Bone Jt Surg. 1995;77(1):73-85.
  22. Yasunaga Y., Ochi M., Terayama H. et al. Rotational acetabular osteotomy for hip dysplasia: 61 hips followed for 8-15 years. Acta Orthop Scand. 2004;75(1):10-15.

Copyright (c) 2016



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies