VREDEN RUSSIAN RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPEDICS

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Abstract

Currently, the use of bone allografts for reconstructive orthopedic surgery in clinical practice around the world is becoming a common procedure. Bone allografts are the first substitute material to the autologous bone and the best alternative to any artificial substituting material. The methods used for the preservation, processing and sterilization of bone are changing and evolving with time. The main goals remain the same including exclusion of infections and creation of the material with sustained properties of the normal bone.

The present review reflects the essential methods for biological tissue processing, sterilization and preservation with the analysis of the key requirements for manufacturing of safe allogeneic osteoplastic materials with osteoinductive, osteoconductive and osteogenic properties.

About the authors

K. A. Vorobyоv

Vreden Russian Research Institute of Traumatology and Orthopedics

Author for correspondence.
Email: vorobyov_doc@mail.ru

Konstantin A. Vorobyоv – Researcher, Research Department of Experimental Morphology

8, ul. Akad. Baykova, St. Petersburg, 195427

Russian Federation

S. A. Bozhkova

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Svetlana A. Bozhkova — Dr. Sci. (Med.), Head of the Research Department of Prevention and Treatment of Wound Infection and Department of Clinical Pharmacology 

8, ul. Akad. Baykova, St. Petersburg, 195427

Russian Federation

R. M. Tikhilov

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Rashid M. Tikhilov — Dr. Sci. (Med.) Professor Director 

8, ul. Akad. Baykova, St. Petersburg, 195427

Russian Federation

A. Zh. Cherny

Vreden Russian Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Черный Андрей Жоржевич – кандидат медицинских наук, заместитель директора по лечебной работе 

Ул. Акад. Байкова, д. 8, Санкт-Петербург, 195427

Russian Federation

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