Manifestations of undifferetiated connective tissue dysplasia in children with cerebral palsy

Objective - to reveal the phenotypic features of undifferentiated connective tissue dysplasia in the form of dysplastic syndrome. Material and methods. The study included 477 children (240 boys and 237 girls) with cerebral palsy (CP) aged from 1 year to 17. The control group consisted of 134 healthy children (70 boys and 64 girls) aged from 2 to 16. For verification of undifferentiated connective tissue dysplasia international phenotypic Glesby scale, Abakumova scale and Kadurina and Gorbunova scale were applied. Results. Depending on used criteria, the clinical signs of dysplastic syndrome were found in 77,3-80,9% of children with cerebral palsy compared with 14,2-15,7% in the control group. There were statistically highly significant (p <0,001) difference in the number of markers and the severity of the dysplastic syndrome in children with cerebral palsy compared with healthy children and children with double hemiplegia in comparison with other forms of cerebral palsy. It was concluded that the CP should be seen as a manifestation of systemic organ dysplasia (dysplastic syndrome). This should be considered during the examination, choosing the tactics of conservative treatment with the principle of "control ripening," The timing and methods of surgical repair of motor disorders in children with cerebral palsy.

диспластический синдром, недифференцированная дисплазия соединительной ткани, детский церебральный паралич у детей, dysplastic syndrome, undifferentiated connective tissue dysplasia, infantile cerebral palsy