Traumatology and Orthopedics of RussiaTraumatology and Orthopedics of RussiaТравматология и ортопедия России2311-29052542-0933Vreden National Medical Research Center of Traumatology and Orthopedics94410.21823/2311-2905-2018-24-1-144-154ReviewsОбзорыReviewsACETYLSALICYLIC ACID FOR THROMBOEMBOLISM PROPHYLAXIS. DOES IT REALLY WORK OR IT’S A GRIMACE OF THE EVIDENCE-BASED MEDICINE?АЦЕТИЛСАЛИЦИЛОВАЯ КИСЛОТА ДЛЯ ПРОФИЛАКТИКИ ТРОМБОЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ. РЕАЛЬНО РАБОТАЕТ ИЛИ ГРИМАСА ДОКАЗАТЕЛЬНОЙ МЕДИЦИНЫ?SeredaA. P.СередаА. П.
Russian Federation

Dr. Sci. (Med), Deputy Head

30, Volokolamskoye shosse, 23182, Moscow

д-р мед. наук, заместитель руководителя 

Волоколамское шоссе, д. 30, стр. 1, 23182, Москва

drsereda@gmail.comFederal Medical Biological AgencyФедеральное медико-биологическое агентство России160420182411441541504201815042018https://journal.rniito.org/jour/article/view/944

Acetylsalicylic acid administration for pharmaceutical prophylaxis of thromboembolic complications is a highly controversial and debatable issue. Debates continue, and, in particularly, opposite views of ACCP recommendations (8th and 9th revisions), Russian clinical recommendations and AAOS guideline were discussed during the Vreden’s Readings conference in 2017 and motivated the authors to compile the present analytical review. The authors attempted to explain initial ban for use and later on sudden advisable use of acetylsalicylic acid for thromboembolism prophylaxis. There can be no unique answer to such a problem due to ambiguity of current state of evidence-based medicine and current system for defining the clinical guidelines.

Использование ацетилсалициловой кислоты для фармакологической профилактики тромбоэмболических осложнений — весьма спорный и дискутабельный вопрос. Не прекращающиеся дискуссии, в частности, на последних «Вреденовских чтениях» в 2017 г. о противоречиях в рекомендациях American College of Chest Physicians восьмой и девятой редакций, Российских клинических рекомендаций и гайдлайна AAOS побудили написать этот аналитический обзор. Мы попытались объяснить, почему сначала ацетилсалициловая кислота запрещалась, а потом вдруг стала разрешена для профилактики тромбоэмболических осложнений. Ответ на этот вопрос не может быть однозначным, поскольку неоднозначна сама современная система доказательной медицины и формулирования клинических рекомендаций.

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