Traumatology and Orthopedics of RussiaTraumatology and Orthopedics of RussiaТравматология и ортопедия России2311-29052542-0933Vreden National Medical Research Center of Traumatology and Orthopedics29610.21823/2311-2905-2012--4-126-134ReviewsОбзорыReviewsOSSEOINTEGRATION IN RECONSTRUCTIVE SURGERY: CONTEMPORARY STATE AND PERSPECTIVES OF FURHTHER DEVELOPMENT (REVIEW)ОСТЕОИНТЕГРАЦИЯ В РЕКОНСТРУКТИВНОЙ ХИРУРГИИИ: СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ РАЗВИТИЯ НАПРАВЛЕНИЯ (ОБЗОР ЛИТЕРАТУРЫ)ShevtsovM. A.ШевцовМ. А.
Russian Federation
Shevtsov-max@mail.ruGalibinO. V.ГалибинО. В.
Russian Federation
ogalibin@mail.ruYudintcevaN. M.ЮдинцеваН. М.
Russian Federation
yudintceva@mail.ruBlinovaM. I.БлиноваМ. И.
Russian Federation
mira.blinova@mail.ruPinaevG. P.ПинаевГ. П.
Russian Federation
pinaev@mail.cytspb.rssi.ruScherbinaK. K.ЩербинаК. К.
Russian Federation
reabin@nkl.ruShvedovchenkoI. V.ШведовченкоИ. В.
Russian Federation
reabin@nkl.ruPitkinM.ПиткинМ. Р.
Russian Federation
mpitkin@tuftsmedicalcenter.orgInstitute of cytology of RASФГБУН «Институт цитологии РАН»I.P. Pavlov State Medical UniversityИнститут детской гематологии и трансплантологии им. Р.М. ГорбачевойI.P. Pavlov State Medical UniversityСанкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаSt.Petersburg Albrecht Research Center for Occupational Expertise, Prosthetics and RehabilitationФГБУ «Санкт-Петербургский научно-практический центр медико-социальной экспертизы, протезирования и реабилитации инвалидов им. Г.А. Альбрехта» Минтруда РоссииTufts UniversityТафтский университет3012201218412613401112016https://journal.rniito.org/jour/article/view/296

Method of intraosseous prosthesis based on the principle of osseointegration that was introduced by Prof. Per-Ingvar Branemark is one of the most perspective approaches in contemporary reconstructive surgery This method helps to achieve increased functional activity and to improve patients quality of life in comparison to conventional treatment. In presented article the results of prosthetic treatment of amputees of different localizations, application of this technology in cranio-fascial surgery, finger joint prostheses are discussed.

Метод внутрикостного протезирования, основанный на принципе остеоинтеграции, который был предложен проф. Per-Ingvar Branemark, является одним из перспективных направлений в современной реконструктивной хирургии. Описанный подход позволяет достичь более высоких показателей функциональной активности пациентов и повысить качество жизни по сравнению с традиционной технологией протезирования. В представленном обзоре обсуждаются результаты лечения больных с ампутациями различной локализации, применения технологии в кранио-фациальной хирургии, протезировании суставов.

остеоинтеграцияпротезированиереабилитацияаурикулярные протезыампутация верхней конечностиампутация нижней конечностиosseointegrationprosthesisrehabilitationauricular prosthesesupper limb amputationlower limb amputationAbu-Serriah M.M., McGowan D.A., Moos K.F., Bagg J. Outcome of extra-oral craniofacial endosseous implants. Br. J. Oral Maxillofac. Surg. 2001; 39: 269-275.Arens S., Schlegel U., Printzen G., Ziegler W.J., Perren S.M., Hansis M. Influence of materials for fixation implants on local infection: an experimental study of steel versus titanium DCP in rabbits. J. Bone Joint Surg. Br. 1996; 78: 647-651.Aschoff H.H., Clausen A., Tsoumpris K., Hoffmeister T. Implantation der Endo-Exo-Femurprothese zur verbesserung der mobilitat amputierter patienten. Oper. Orthop. Traumatol. 2011; 23: 462-472.Blinova M.I., Yudintzeva N.M., Nikolaenko N.S., Potokin I.L., Raykhtsaum G., Pitkin M.R., Pinaev G.P. Cell cultivation on porous titanium implants with various structures. Cell and tissue biol. 2010; 4: 572-579.Branemark P.I., Hansson B.O., Adell R., Breine U., Lindstrom J., Hallen O., Ohman A. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand. J. Plast. Reconstr. Suppl. 1977; 16: 1-132.Chung E.H., Gilbert M., Virdi A.S., Sena K., Sumner D.R., Healy K.E. Biomimetic artificial ECMs stimulate bone regeneration. J. Biomed. Mater. Res. A. 2006; 79: 815-826.Cordero J., Munuera L., Folgueira M.D. Influence of metal implants on infection: an experimental study in rabbits. J. Bone Joint Surg. Br. 1994; 76:717-720.Dahlstrom L. A summary of the work of Torgny Haraldson. In: Williams E., Rydevik B., Johns R., Branemark P.-I., editors. Osseoperception and musculo-skeletal function. The Institute for Applied Biotechnology, 1999. p. 68-85.De R.A., Virdi A.S., Kuroda S., Shott S., Leven R.M., Hallab N.J., Sumner D.R. Local application of rhTGF-beta2 enhances peri-implant bone volume and bone-implant contact in a rat model. Bone. 2005; 37:55-62.Dillingham T.R., Pezzin L., MacKenzie E. Limb amputation and limb deficiency: Epidemiology and recent trends in the United States. Southern Medical J. 2002; 95:875-883.Dillow A.K., Ochsenhirt S.E., McCarthy J.B., Fields G.B., Tirrell M. Adhesion of alpha5beta1 receptors to biomimetic substrates constructed from peptide amphiphiles. Biomaterials. 2001; 22:1493-1505.Doppen P., Solomons M., Kritzinger S. Osseointegrated finger prostheses. J. Hand Surg. Eur. Vol. 2009; 34:29-34.Drinias V., Granstrom G., Tjellstrom A. High age at the time of implant installation is correlated with increased loss of osseointegrated implants in the temporal bone. Clin. Implant. Dent. Relat. Res. 2007; 9:94-99.Frossard L.A., Hagberg K., Haggstrom E., Gow D.L., Branemark R., Pearcy M. Functional outcome of transfemoral amputess fitted with an osteointegration fixation: temporal gait characteristics. J. Prosthet. Orthot. 2010; 22:11-20.Gallagher P., MacLachlan M. Adjustment to an artificial limb: a qualitative perspective. J. Health Psychol. 2001; 6:85-100.Granstrom G., Bergstrom K., Odersjo M., Tjellstrom A. Osseointegrated implants in children: experience from our first 100 patients. Otolaryngol. Head Neck Surg. 2001; 125:85-92.Hagberg K., Branemark P. Consequences of non-vascular trans-femoral amputation: a survey of quality of life, prosthetic use and problems. Prosthet. Orthot. Int. 2001; 25:186-194.Hagberg K., Branemark R. One hundred patients treated with osseointegrated transfemoral amputation prostheses - Rehabilitation perspective. J. Rehabil. Res. Dev. 2009; 46:331-344.Hagberg K., Branemark R., Gunterberg B., Rydevik B. Osseointegrated trans-femoral amputation prostheses: prospective results of general and condition-specific quality of life in 18 patients at 2-year follow-up. Prosthet. Orthot. Int. 2008; 32:29-41.Hagberg K., Haggstrom E., Jonsson S., Rydevik B., Branemark R. Osseoperception and osseointegrated prosthetics limbs. In: Gallagher P., Desmond D., MacLachlan M., ed. Psychoprosthetics. London: Springer; 2008. p. 131-140.Hagberg K., Haggstrom E., Uden M., Branemark R. Socket versus bone-anchored trans-femoral prostheses: hip range of motion and sitting comfort. Prosthet. Orthot. Int. 2005; 29:153-163.Ho J.E., Chung E.H., Wall S., Schaffer D.V., Healy K.E. Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells. J. Biomed. Mater. Res. A. 2007; 83:1200-1208.Infanger M. Improved fixation of finger prostheses by means of intramedullary titanium anchors and magnets. Handchir. Mikrochir. Plast. Chir. 2005; 37:202-206.Jacobs R., Branemark R., Olmarker K., Rydevik R., Van Steenberghe D., Branemark P.-I. Evaluation of the psychophysical detection threshold level for vibrotactile and pressure stimulation of prosthetic limbs using bone anchorage or soft tissue support. Prosthet. Orthot. Int. 2000; 4:133-142.Jang H.W., Kang J.K., Lee K., Lee Y.S., Park P.K. A retrospective study on related factors affecting the survival rate of dental implants. J. Adv. Prosthodont. 2011; 3:204-215.Jonsson S., Caine-Winterberger K., Branemark R. Osseointegration amputation prostheses on the upper limbs: methods, prosthetics and rehabilitation. Prosthet. Orthot. Int. 2011; 35:190-200.Kapp S. Suspension systems for prostheses. Clin. Orthop. Relat. Res. 1999; 361:55-62.Lundberg M., Hagberg K., Bullington J. My prosthesis as a part of me: a qualitative analysis of living with an osseointergrated prosthetic limb. Prosthet. Orthot. Int. 2011; 35:207-214.Lundborg G., Branemark P.I., Carlsson I. Metacarpophalangeal joint arthroplasty based on the osseointegration concept. J. Hand Surg. 1993; 18-B:693-703.Lundborg G., Branemark P.-I. Osseointegrated proximal interphalangeal joint prostheses with a replaceable flexible joint spacer - Long term results. Scand. J. Plast. Reconstr. Hand Surg. 2000; 34:345-353.Lundborg G., Branemark P.-I., Rosen B. Osseointegrated thumb prostheses: a concept for fixation of digit prosthetic devices. J. Hand. Surg. 1996; 221-A:216-221.Manurangsee P., Isariyawut C., Chatuthong V., Mekraksawanit S. Osseointegrated finger prosthesis: An alternative method for finger reconstruction. J. Hand Surg. 2000; 25-A:86-92.Marks L.J., Michael J.W. Science, medicine, and the future: artificial limbs. BMJ. 2001; 323:732-735.Muller P., Bulnheim U., Diener A., Luthen F., Teller M., Klinkenberg E.D., Neumann H.G., Nebe B., Liebold A., Steinhoff G., Rychly J. Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells. J. Cell. Mol. Med. 2008; 12:281-291.Nebergall A., Bragdon C., Antonellis A., Karrholm J., Branemark R., Malchau H. Stable fixation of an osseointegrated implant system for above-the-knee amputees. Titel RSA and radiographic evaluation of migration and bone remodeling in 55 cases. Acta Orthopaedica. 2012; 83:121-128.Nishimura R.D., Roumanas E., Sugai T., Moy P.K. Auricular prostheses and osseointegrated implants: UCLA experience. J. Prosthet. Dent. 1995; 73:553-558.Parel S.M., Tjellstrom A. The United States and Swedish experience with osseointegration and facial prostheses. Int. J. Oral. Maxillofac. Implants. 1991; 6:75-79.Petrie T.A., Reyes C.D., Burns K.L., Garcia A.J. Simple application of fibronectin-mimetic coating enhances osseointegration of titanium implants. J. Cell Mol. Med. 2009; 13:2602-2612.Pitkin M. On the way to total integration of prosthetic pylon with residium. J. Rehabil. Res. Dev. 2009; 46:345-360.Pitkin M., Raykhtsaum G., Pilling J., Shukeylo Y., Moxson V., Duz V., Lewandowski J., Connolly R., Kistenberg R.S., Dalton J.F., Prilutsky B., Jacobson S. Mathematical modeling and histopathological testing of porous prosthetic pylon for direct skeletal attachment. J. Rehabil. Res. Dev. 2009; 46;335-330.Rabuffetti M., Recalcati M., Ferrarin M. Transfemoral amputee gait: socket-pelvis constraints and compensation strategies. Prosthet. Orthot. Int. 2005; 29:183-192.Robinson K.P., Branemark R., Ward D.A. Future developments: Osseointegration in transfemoral amputees. In: Smith D.G., Michael J.W., Bowker J.H., eds. Atlas of amputations and limb deficiencies: Surgical, prosthetic and rehabilitation principles. 3rd ed. Rosemont (IL): American Academy of Orthopaedic Surgeons; 2004. p. 673-682.Rotenberg B.W., James A.L., Fisher D., Anderson J., Papsin B.C. Establishment of a bone-anchored auricular prosthesis (BAAP) program. Int. J. Pediatr. Otorhinolaryngol. 2002; 66:273-279.Roumanas E., Nishimura R., Beumer J., Moy P., Weinlander M., Lorant J. Craniofacial defects and osseointegrated implants: six-year follow-up report on the success rates of craniofacial implants at UCLA. Int. J. Oral. Maxillofac. Implants. 1994; 9:579-585.Shevtsov M.A., Pitkin M., Rayakhtsaum G., Pilling J., Yudentsova N.M., Blinova M.I., Pinaev G.P., Potokin I.L., Protasov M.V., Suslov D.N., Moxson V., Duz V., Ivanova A.A., Savchenko O.N., Galibin O.V. Porous titanium material as a perspective material for reconstructive surgery. 1st Biotechnology World Congress, February 14-15, 2012, Dubai, UAE. Curr. Pharm. Biotech. 2012; 13:22.Sul Y.T. Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw0shaped titanium implants. Int. J. Nanomed. 2010; 5:87-100.Sul Y.T., Johansson C., Byon E., Albrektsson T. The bone response of oxidized bioactive and non-bioactive titanium implants. Biomaterials. 2005; 26:6720-6730.Sullivan J., Uden M., Robinson K.P., Sooriakumaran S. Rehabilitation of the trans-femoral amputee with an osseointegrated prosthesis: the United Kingdom experience. Prosthet. Orthot. Int. 2003; 27:114-120.Sumner D.R., Turner T.M., Urban R.M., Virdi A.S., Inoue N. Additive enhancement of implant fixation following combined treatment with rhTGF-beta2 and rhBMP-2 in a canine model. J. Bone Joint Surg. Am. 2006; 88:806-817.Sundgren J.E., Bodo P., Lundstrom I. Auger electronspectroscopic studies of the interface between human tissue and implants of titanium and stainless steel. J. Coll. Int. Sci. 1986; 110:9-20.Thorne C.H., Brecht L.E., Bradley J.P., Levine J.P., Hammerschlag P., Longaker M.T. Auricular reconstruction: indications for autogenous and prosthetic techniques. Plast. Reconstr. Surg. 2001; 107:1241-1252.Tillander J., Hagberg K., Hagberg L., Branemark R. Osseointegrated titanium implants for limb prostheses attachments. Infectious complications. Clin. Orthop. Relat. Res. 2010; 468:2781-2788.Tjellstrom A. Osseointegrated implants for replacement of absent or defective ears. Clin. Plast. Surg. 1990; 17:355-366.Tjellstrom A. Osseointegrated systems and their applications in the head and neck. Adv. Otolaryngol. Head Neck Surg. 1989; 3:39-70.Tjellstrom A., Yontchev E., Lindstrom J., Branemark P.I. Five years' experience with bone-anchored auricular prostheses. Otolaryngol. Head Neck Surg. 1985; 93:366-372.Tolman D.E., Taylor P.F. Bone-anchored craniofacial prosthesis study. Int. J. Oral. Maxillofac. Implants. 1996; 11:159-168.Tranberg R., Zugner R., Karrholm J. Improvements in hip- and pelvic motion for patients with osseointegrated trans-femoral prostheses. Gait Posture. 2011; 33:165-168.Wazen J.J., Wright R., Hatfield R.B., Asher E.S. Auricular rehabilitation with bone-anchored titanium implants. Laryngoscope. 1999; 109:523-527.Westin T., Tjellstrom A., Hammerlid E., Bergstrom K., Rangert B. Long-term study of quality and safety of osseointegration for the retention of auricular prostheses. Otolaryngol. Head Neck Surg. 1999; 121: 133-143.Zwilling V., Aucouturier M., Darque-Ceretti E. Anodic oxidation of titanium and TA6V alloy in chromic media. An electrochemical approach. Electrochimi. Acta. 1999; 45: 921-929.