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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17681</article-id><article-id pub-id-type="doi">10.17816/2311-2905-17681</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>EXPERIENCE EXCHANGE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБМЕН ОПЫТОМ</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Experience exchange</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Locked Plate Impregnated with Antibiotic-Loaded Bone Cement Application as a First Stage For Managing Long Bones Infected Nonunion: A Technical Note</article-title><trans-title-group xml:lang="ru"><trans-title>Применение накостной пластины с цементной антимикробной мантией на первом этапе лечения инфицированных несращений длинных костей: техническая заметка</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-1046-3584</contrib-id><name-alternatives><name xml:lang="en"><surname>Tawfeek</surname><given-names>Michael G.</given-names></name><name xml:lang="ru"><surname>Тауфик</surname><given-names>Майкл Г.</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="EG">Egypt</country></address><bio xml:lang="en"><p>MSc, Assiut University Trauma Hospital, Faculty of Medicine</p></bio><bio xml:lang="ru"><p>Assiut University Trauma Hospital, Faculty of Medicine</p></bio><email>maykel_PG1148893@med.aun.edu.eg</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0710-6487</contrib-id><name-alternatives><name xml:lang="en"><surname>Khalifa</surname><given-names>Ahmed A.</given-names></name><name xml:lang="ru"><surname>Халифа</surname><given-names>Ахмед А.</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="EG">Egypt</country></address><bio xml:lang="en"><p>Assistant Professor, Qena faculty of medicine and University Hospital</p></bio><bio xml:lang="ru"><p>доцент, Qena faculty of medicine and University Hospital</p></bio><email>ahmed_adel0391@med.svu.edu.eg</email></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2103-3322</contrib-id><name-alternatives><name xml:lang="en"><surname>Abubeih</surname><given-names>Hossam</given-names></name><name xml:lang="ru"><surname>Абу-Бейх</surname><given-names>Хоссам</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="EG">Egypt</country></address><bio xml:lang="en"><p>MD, Assiut University Trauma Hospital, Faculty of Medicine</p></bio><bio xml:lang="ru"><p>Assiut University Trauma Hospital, Faculty of Medicine</p></bio><email>hossamabubeih@hotmail.com</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Badran</surname><given-names>Mahmoud</given-names></name><name xml:lang="ru"><surname>Бадран</surname><given-names>Махмуд</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="EG">Egypt</country></address><bio xml:lang="en"><p>MD, Assiut University Trauma Hospital, Faculty of Medicine</p></bio><bio xml:lang="ru"><p>Assiut University Trauma Hospital, Faculty of Medicine</p></bio><email>mahmoud.badran@aun.edu.eg</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3897-6485</contrib-id><name-alternatives><name xml:lang="en"><surname>Farouk</surname><given-names>Osama</given-names></name><name xml:lang="ru"><surname>Фарук</surname><given-names>Осама</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="EG">Egypt</country></address><bio xml:lang="en"><p>MD, Assiut University Trauma Hospital, Faculty of Medicine</p></bio><bio xml:lang="ru"><p>Assiut University Trauma Hospital, Faculty of Medicine</p></bio><email>farouk-o@aun.edu.eg</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Assiut University</institution></aff><aff><institution xml:lang="ru">Assiut University</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Qena Health Insurance Hospital</institution></aff><aff><institution xml:lang="ru">Qena Health Insurance Hospital</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">South Valley University</institution></aff><aff><institution xml:lang="ru">South Valley University</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff id="aff4"><institution>Assiut University</institution></aff><pub-date date-type="preprint" iso-8601-date="2025-04-25" publication-format="electronic"><day>25</day><month>04</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-06-11" publication-format="electronic"><day>11</day><month>06</month><year>2025</year></pub-date><volume>31</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>153</fpage><lpage>160</lpage><history><date date-type="received" iso-8601-date="2025-02-20"><day>20</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-04-14"><day>14</day><month>04</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/17681">https://journal.rniito.org/jour/article/view/17681</self-uri><abstract xml:lang="en"><p><bold>Background</bold>. Infected nonunion of long bone fractures poses a dilemma for trauma surgeons, especially when accompanied by bone defects. The main goals for management are curing infection, reconstructing the bone defect, achieving union at the fracture site, and eventually obtaining acceptable functional outcomes. In these situations, the surgeon could manage the infected nonunion through single-stage surgery. However, some surgeons prefer two-stage surgical intervention, wherein in the first stage, all attention is paid to curing the infection and providing temporary stabilization till the second stage, which is the definitive fixation. Temporary fixation during the first stage after thorough debridement could be obtained by various methods, including intramedullary nails coated by bone cement or external fixators.</p> <p><bold>The aim </bold>— to describe a modification while using a locked plate impregnated with antibiotic-loaded bone cement during</p> <p>the first stage of two-stage revision for managing infected nonunited distal femoral fracture.</p> <p><bold>Technique description</bold>. The method described in the current technical note is a locking plate impregnated with antibiotic-loaded bone cement. This technique provides optimal local antibiotic delivery through the bone cement and proper stability owing to the fixation using the locking plate, which could be applied as close to the bone as possible due to its function as an internal-external fixator.</p> <p><bold>Conclusion</bold>. The technique is easy and efficient and can be applied using ordinary tools without needing complex instruments.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Актуальность.</bold> Инфицированное несращение переломов длинных костей может вызывать сложности у травматологов, особенно если оно сопровождается костными дефектами. Основными целями лечения являются купирование инфекции, замещение костного дефекта, сращение в месте перелома и, в конечном итоге, достижение удовлетворительных функциональных результатов. При выборе тактики лечения инфицированного несращения хирург может выбрать одноэтапную операцию, однако некоторые предпочитают двухэтапное хирургическое вмешательство, при котором на первом этапе все внимание уделяется лечению инфекции и обеспечению временной стабилизации до второго этапа, на котором осуществляется окончательная фиксация. Временная фиксация на первом этапе после тщательной санации может быть достигнута различными методами, включая интрамедуллярный стержень с цементным покрытием или внешние фиксаторы.</p> <p><bold>Цель</bold> — описать модификацию применения накостной пластины, покрытой цементной антимикробной мантией, на первом этапе двухэтапной ревизии при лечении инфицированного несросшегося перелома дистального отдела бедренной кости.</p> <p><bold>Описание техники. </bold>Метод, описанный в данной работе, заключается в использовании фиксирующей пластины, покрытой смесью костного цемента с антибиотиком. Эта техника обеспечивает местную доставку антибиотика через костный цемент и надлежащую стабильность благодаря фиксации с помощью пластины, которая может быть установлена как можно ближе к кости благодаря своей функции внутреннего фиксатора.</p> <p><bold>Заключение. </bold>Техника проста в использовании и эффективна, ее можно применять с помощью обычных инструментов, не прибегая к сложным приборам.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>infected nonunion</kwd><kwd>bone cement spacer</kwd><kwd>local antibiotic therapy</kwd><kwd>antibiotic cement-impregnated locking plate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфицированное несращение</kwd><kwd>спейсер из костного цемента</kwd><kwd>локальная антибактериальная терапия</kwd><kwd>накостная пластина</kwd><kwd>цементное антимикробное покрытие</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Flores M.J., Brown K.E., O’Marr J.M., Adejuyigbe B., Rodarte P., Gomez-Alvarado F. et al. The economic impact of infection and/or nonunion on long-bone shaft fractures: a systematic review. OTA Int. 2024;7(3):e337. doi: 10.1097/OI9.0000000000000337.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Metsemakers W.J., Morgenstern M., Senneville E., Borens O., Govaert G.A.M., Onsea J. et al. General treatment principles for fracture-related infection: recommendations from an international expert group. Arch Orthop Trauma Surg. 2020;140(8):1013-1027. doi: 10.1007/s00402-019-03287-4.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Govaert G.A.M., Kuehl R., Atkins B.L., Trampuz A., Morgenstern M., Obremskey W.T. et al. Diagnosing Fracture-Related Infection: Current Concepts and Recommendations. J Orthop Trauma. 2020;34(1):8-17. doi: 10.1097/BOT.0000000000001614.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Bauer T., Klouche S., Grimaud O., Lortat-Jacob A., Hardy P. Treatment of infected non-unions of the femur and tibia in a French referral center for complex bone and joint infections: Outcomes of 55 patients after 2 to 11 years. Orthop Traumatol Surg Res. 2018;104(1):137-145. doi: 10.1016/j.otsr.2017.10.014.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Farouk O., Khalifa A.A. Tibial Bone Loss: How to Treat without Circular Fixation? J Orthop Spine Trauma. 2023;9(1):1-5. doi: 10.18502/jost.v9i1.12561.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Migliorini F., Schäfer L., Simeone F., Vaish A., Bhadani J.S., Vaishya R. Management of Distal Femoral Non-union: A Systematic Review. Indian J Orthop. 2024;58(12):1686-1723. doi: 10.1007/s43465-024-01205-4.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Somford M.P., van den Bekerom M.P., Kloen P. Operative treatment for femoral shaft nonunions, a systematic review of the literature. Strategies Trauma Limb Reconstr. 2013;8(2):77-88. doi: 10.1007/s11751-013-0168-5.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Khalifa A.A., Fadle A.A., Elsherif M.E., Said H.G., Elsherif E., Said G. et al. Concomitant intramedullary nailing and plate augmentation as a single-stage procedure in treating complicated nonunited femoral shaft fractures. Trauma. 2021;24(4):286-293. doi: 10.1177/14604086211007037.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Barabash A.P., Kesov L.A., Barabash Ju.A., Shpinyak S.P. Building of extensive diaphysis defects in long bones. Traumatology and Orthopedics of Russia. 2014;20(2):93-99. (In Russian). doi: 10.21823/2311-2905-67.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Yang X., Xu X., Li J., Song M., Sun H., Zhang H. et al. Management of infected bone defects of the femoral shaft by Masquelet technique: sequential internal fixation and nail with plate augmentation. BMC Musculoskelet Disord. 2024;25(1):552. doi: 10.1186/s12891-024-07681-x.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bu Z.Y., Hu L.J., Li C., Li A.J. Clinical analysis of application of antibiotic bone cement spacer combined with membrane induction technology in treatment of osteomyelitis after femoral intramedullary nail operation – A case series. J Pak Med Assoc. 2020;70(2):360-362. doi: 10.5455/JPMA.9552.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Solanki T., Maurya M.K., Singh P.K. Results of Antibiotic-Impregnated Cement/Polymer-Coated Intramedullary Nails in the Management of Infected Nonunion and Open Fractures of Long Bones. Cureus. 2023;15(8):e43421. doi: 10.7759/cureus.43421.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Garabano G., Pereira S., Alamino L.P., Munera M.A., Ernst G., Bidolegui F. et al. Antibiotic cement-coated rigid locked nails in infected femoral and tibial nonunion. Reoperation rates of commercial versus custom-made nails. Injury. 2023;54(Suppl 6):110650. doi: 10.1016/j.injury.2023.02.033.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Romanò C.L., Bozhkova S.A., Artyukh V., Romanò D., Tsuchiya H., Drago L. Local Antibacterial Implant Protection in Orthopedics and Trauma: What’s New? Traumatology and Orthopedics of Russia. 2019;25(4):64-74. doi: 10.21823/2311-2905-2019-25-4-64-74.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Jia C., Wang X., Yu S., Wu H., Shen J., Huang Q. et al. An antibiotic cement-coated locking plate as a temporary fixation for treatment of infected bone defects: a new method of stabilization. J Orthop Surg Res. 2020;15(1):44. doi: 10.1186/s13018-020-1574-2.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Qiu X.S., Cheng B., Chen Y.X., Qi X.Y., Sha W.P., Chen G.Z. Coating the plate with antibiotic cement to treat early infection after fracture fixation with retention of the implants: a technical note. BMC Musculoskelet Disord. 2018;19(1):360. doi: 10.1186/s12891-018-2285-2.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Wang X., Wang S., Xu J., Sun D., Shen J., Xie Z. Antibiotic cement plate composite structure internal fixation after debridement of bone infection. Sci Rep. 2021;11(1):16921. doi: 10.1038/s41598-021-96522-1.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Bidolegui F., Codesido M., Pereira S., Abraham A., Pires R.E., Giordano V. Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia. Rev Col Bras Cir. 2023;49:e20223060. doi: 10.1590/0100-6991e-20223060-en.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Keller D.M., Pizzo R.A., Patel J.N., Viola A., Yoon R.S., Liporace F.A. Use of antibiotic-cement coated locking plates in the setting of periprosthetic infection and infected nonunion. Injury. 2022;53(7):2567-2572. doi: 10.1016/j.injury.2022.03.040.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Metsemakers W.J., Morgenstern M., McNally M.A., Moriarty T.F., McFadyen I., Scarborough M. et al. Fracture-related infection: A consensus on definition from an international expert group. Injury. 2018;49(3):505-510. doi: 10.1016/j.injury.2017.08.040.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Afanasyev A.V., Bozhkova S.A., Artyukh V.A. Predictors for Recurrence of Chronic Osteomyelitis Following Long Bones Cavity Defect Replacement with Synthetic Materials. Traumatology and Orthopedics of Russia. 2024;30(4):14-24. (In Russian). doi: 10.17816/2311-2905-17591.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Azi M.L., Teixeira A.A.A., Cotias R.B., Joeris A., Kfuri M. Induced-Membrane Technique in the Management of Posttraumatic Bone Defects. JBJS Essent Surg Tech. 2019;9(2):e22. doi: 10.2106/JBJS.ST.18.00099.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Kadhim M., Holmes L. Jr., Gesheff M.G., Conway J.D. Treatment Options for Nonunion With Segmental Bone Defects: Systematic Review and Quantitative Evidence Synthesis. J Orthop Trauma. 2017;31(2):111-119. doi: 10.1097/BOT.0000000000000700.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Rupp M., Kern S., Walter N., Anastasopoulou L., Schnettler R., Heiss C. et al. Surgical treatment outcome after serial debridement of infected nonunion – A retrospective cohort study. Eur J Orthop Surg Traumatol. 2022;32(1):183-189. doi: 10.1007/s00590-021-02930-4.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Schmidt A.H., Swiontkowski M.F. Pathophysiology of infections after internal fixation of fractures. J Am Acad Orthop Surg. 2000;8(5):285-291. doi: 10.5435/00124635-200009000-00002.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Berkes M., Obremskey W.T., Scannell B., Ellington J.K., Hymes R.A., Bosse M. et al. Maintenance of hardware after early postoperative infection following fracture internal fixation. J Bone Joint Surg Am. 2010;92(4):823-828. doi: 10.2106/JBJS.I.00470.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Zhu Y., Jiang P., He Z., Qian H. Non-contact locking plate: A useful alternative to external fixation in second-stage treatment of post-traumatic tibial osteomyelitis. Exp Ther Med. 2024;27(5):230. doi: 10.3892/etm.2024.12518.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Savchuk O.P., Tapalski D.V., Zinovkin D.A., Nikolaev V.I., Yarmolenko M.A., Rogachev A.A. Perifocal Soft Tissue Reactions in Response to Contaminated Implants With a Composite Antibacterial Coating: Experimental Study. Traumatology and Orthopedics of Russia. 2023;29(1): 36-45. doi: 10.17816/2311-2905-2000.</mixed-citation></ref></ref-list></back></article>
