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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17601</article-id><article-id pub-id-type="doi">10.17816/2311-2905-17601</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case Reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Случаи из практики</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Case Reports</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Simultaneous bilateral avascular necrosis of the humerus and femur in long COVID-19: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Двусторонний аваскулярный некроз головок плечевых и бедренных костей как проявление постковидного синдрома: клинический случай</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3627-3882</contrib-id><name-alternatives><name xml:lang="en"><surname>Bakır</surname><given-names>Mesut</given-names></name><name xml:lang="ru"><surname>Бакыр</surname><given-names>Месут</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="TR">Turkey</country></address><bio xml:lang="en"><p>MD. Assoc. professor</p></bio><bio xml:lang="ru"><p>доцент</p></bio><email>mesutbakir@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7042-6934</contrib-id><name-alternatives><name xml:lang="en"><surname>Rumeli</surname><given-names>Şebnem</given-names></name><name xml:lang="ru"><surname>Румели</surname><given-names>Шебнем</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="TR">Turkey</country></address><bio xml:lang="en"><p>MD, Professor</p></bio><bio xml:lang="ru"><p>профессор</p></bio><email>sebnemrumeli66@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Mersin University, Faculty of Medicine, Division of Algology</institution></aff><aff><institution xml:lang="ru">Mersin University, Faculty of Medicine, Division of Algology</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-11-27" publication-format="electronic"><day>27</day><month>11</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-12-18" publication-format="electronic"><day>18</day><month>12</month><year>2024</year></pub-date><volume>30</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>140</fpage><lpage>145</lpage><history><date date-type="received" iso-8601-date="2024-08-23"><day>23</day><month>08</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-10-14"><day>14</day><month>10</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/17601">https://journal.rniito.org/jour/article/view/17601</self-uri><abstract xml:lang="en"><p><bold>Background. </bold>The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted the widespread use of corticosteroids as a treatment strategy, particularly in cases of severe pneumonia and cytokine storm. While this therapy has saved countless lives, its side effects have also been well-documented, including the development of avascular necrosis.</p> <p><bold>Case presentation. </bold>This case report presents a rare instance of simultaneous bilateral avascular necrosis (AVN) affecting both the humeral and femoral heads in a 49-year-old male patient recovering from severe COVID-19. The patient was treated with high-dose corticosteroids, receiving 1250 mg of prednisolone over five days during hospitalization for COVID-19 pneumonia. Six months after discharge, he developed persistent hip pain, which was later diagnosed as AVN in both femoral heads. During hyperbaric oxygen therapy, the patient reported new shoulder pain, and MRI confirmed stage III AVN in both humeral heads. The patient’s pain was managed with bilateral suprascapular nerve radiofrequency ablation and bilateral Pericapsular Nerve Group (PENG) blocks, which provided significant relief.</p> <p><bold>Conclusions.</bold> This case emphasizes the potential for corticosteroid-induced AVN, even months after treatment, and underscores the need for long-term monitoring of patients receiving corticosteroids for COVID-19. The involvement of four major joints highlights the severe musculoskeletal complications that can arise, supporting the importance of early diagnosis and timely intervention for pain relief.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Актуальность. </bold>Пандемия COVID-19, вызванная распространением коронавируса тяжелого острого респираторного синдрома 2 (SARS-CoV-2), привела к широкому применению кортикостероидов, особенно в случаях тяжелой пневмонии и гиперцитокинемии. Хотя эта терапия спасла бесчисленное множество жизней, уже накоплены сведения о ее побочных эффектах, включая развитие аваскулярного некроза костей.</p> <p><bold>Описание случая.</bold> Представлен редкий случай двустороннего аваскулярного некроза головок плечевых и бедренных костей у мужчины 49 лет, перенесшего тяжелую форму COVID-19. В качестве лечения пациенту назначались высокие дозы кортикостероидных препаратов — 1250 мг преднизолона в течение 5 дней во время госпитализации по поводу COVID-19-ассоциированной пневмонии. Спустя 6 мес. после выписки у пациента появились постоянные боли в области тазобедренного сустава, позднее диагностированные как аваскулярный некроз обеих головок бедренных костей. В ходе гипербарооксигенотерапии пациент также сообщил о возникшей боли в плече. Магнитно-резонансная томография подтвердила III стадию аваскулярного некроза обеих головок плечевых костей. Боль была устранена при помощи радиочастотной абляции надлопаточного нерва и блокады группы перикапсулярных нервов с обеих сторон, что значительно улучшило состояние пациента.</p> <p><bold>Заключение.</bold> Представленный случай подтверждает возможность развития аваскулярного некроза вследствие лечения кортикостероидами даже спустя месяцы после завершения терапии. В связи с этим необходимо уделять особое внимание долгосрочному наблюдению пациентов, принимавших кортикостероидные препараты в качестве лечения при COVID-19. Поражение четырех крупных суставов свидетельствует о потенциальных тяжелых последствиях данного осложнения для опорно-двигательного аппарата и подчеркивает важность ранней диагностики и своевременного вмешательства для купирования боли.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>avascular necrosis</kwd><kwd>hip</kwd><kwd>shoulder</kwd><kwd>corticosteroid therapy</kwd><kwd>COVID-19 complications</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аваскулярный некроз</kwd><kwd>тазобедренный сустав</kwd><kwd>плечевой сустав</kwd><kwd>кортикостероидная терапия</kwd><kwd>постковидные осложнения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bahsoun A., Fakih Y., Zareef R., Bitar F., Arabi M. Corticosteroids in COVID-19: pros and cons. 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