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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17582</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>FOR PRACTICIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Miscellaneous</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hyaluronic Acid in Traumatology and Orthopedics. Orthobiological Aspects. Сonsensus project</article-title><trans-title-group xml:lang="ru"><trans-title>Препараты гиалуроновой кислоты в травматологии и ортопедии. Ортобиологические аспекты. Проект консенсуса</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><pub-date date-type="pub" iso-8601-date="2024-07-04" publication-format="electronic"><day>04</day><month>07</month><year>2024</year></pub-date><volume>30</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>215</fpage><lpage>230</lpage><history><date date-type="received" iso-8601-date="2024-07-04"><day>04</day><month>07</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-07-04"><day>04</day><month>07</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/17582">https://journal.rniito.org/jour/article/view/17582</self-uri><abstract xml:lang="en"><p>The article presents a preliminary version accepted at the V Congress Orthobiologics 2024 «Consensus in clinical practice» (19-20 Apr 2024). The final version will be published as soon as the reviewers’ and expert group’s comments are implemented. The consensus paper on the use of hyaluronic acid-based injectants has been created. The paper is aimed to optimize their use regulations in various musculoskeletal disorders. The mechanisms of action, biological effects, clinical efficiency and safety of use of hyaluronic acid in various pathological conditions are described. Legal fundamentals, scientific and clinical perspectives of using hyaluronic acid therapy in clinical practice are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Предварительная версия, принята на V Конгрессе ОРТОБИОЛОГИЯ 2024 «Консенсусы в клинической практике» (19–20 апреля 2024 года). Финальная версия будет опубликована после учета замечаний рецензентов и экспертной группы. Создание согласительного документа по применению инъекционных препаратов на основе гиалуроновой кислоты для оптимизации регламентов их использования при различных патологиях опорно-двигательного аппарата. Описаны механизмы действия, биологические эффекты, клиническая эффективность и безопасность применения препаратов гиалуроновой кислоты при различных патологических состояниях. Представлены юридические основы, научные и клинические перспективы терапии препаратами гиалуроновой кислоты в клинической практике.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Costa F.R., Costa Marques M.R., Costa V.C., Santos G.S., Martins R.A., Santos M.D.S. et al. Intra-Articular Hyaluronic Acid in Osteoarthritis and Tendinopathies: Molecular and Clinical Approaches. Biomedicines. 2023;11(4):1061. doi: 10.3390/biomedicines11041061.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Walker K., Basehore B.M., Goyal A., Zito P.M. Hyaluronic Acid. Treasure Island: StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482440/.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Liu L., Liu Y., Li J., Du G., Chen J. Microbial production of hyaluronic acid: current state, challenges, and perspectives. Microb Cell Fact. 2011;10:99. doi: 10.1186/1475-2859-10-99.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Fraser J.R.E., Laurent T.C., Laurent U.B.G. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997;242:27-33. doi: 10.1046/j.1365-2796.1997.00170.x.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Boeriu C.G., Springer J., Kooy F.K., van den Broek L.A.M., Eggink G. Production methods for hyaluronan. Int J Carbohydr Chem. 2013;2013: 1-14. doi: 10.1155/2013/624967.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Shiedlin A., Bigelow R., Christopher W., Arbabi S., Yang L., Maier R.V. et al. Evaluation of hyaluronan from different sources: Streptococcus zooepidemicus, rooster comb, bovine vitreous, and human umbilical cord. Biomacromolecules. 2004;5:2122-2127. doi: 10.1021/bm0498427.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mao Z., Chen R.R. Recombinant synthesis of hyaluronan by Agrobacterium sp. Biotechnol Prog. 2007;23:1038-1042. doi: 10.1021/bp070113n.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Widner B., Behr R., Von Dollen S., Tang M., Heu T., Sloma A. et al. Hyaluronic acid production in Bacillus subtilis. Appl Env Microbiol. 2005;71:3747-3752. doi: 10.1128/AEM.71.7.3747-3752.2005.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Страхов М.А., Скороглядов А.В. Современные тенденции использования средств, замещающих синовиальную жидкость, на основе связанной гиалуроновой кислоты в лечении пациентов с травмами и заболеваниями опорно-двигательного аппарата. Вестник травматологии и ортопедии им. Н.Н. Приорова. 2013;20(4):85-91. doi: 10.17816/vto20130485-91. Strakhov M.A., Skoroglyadov A.V. Modern tendencies of synovial fluid substituting drugs based on bound hyaluronic acid use in treatment of patients with loco-motor system pathology and injuries. N.N. Priorov journal of traumatology and orthopedics. 2013;20(4): 85-91. (In Russian). doi: 10.17816/vto20130485-91.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Boeriu C.G., Springer J., Kooy F.K., van den Broek L.A.M., Eggink G. Production methods for hyaluronan. Int J Carbohydr Chem. 2013;2013:1-14. doi: 10.1155/2013/624967.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Jing W., Deangelis P.L. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem. 2004;279:42345-42349. doi: 10.1074/jbc.M402744200.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Sze J.H., Brownlie J.C., Love C.A. Biotechnological production of hyaluronic acid: a mini review. 3 Biotech. 2016;6(1):67. doi: 10.1007/s13205-016-0379-9.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Ghosh P., Guidolin D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis; are the effects molecular weight dependent? Sem Arthr Rheum. 2002;32:10-37. doi: 10.1053/sarh.2002.33720.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Ström A., Larsson A., Okay O. Preparation and physical properties of hyaluronic acid-based cryogels. J Appl Polym Sci. 2015;132(29):1-11. doi: 42194 10.1002/app.42194.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Conrozier T., Chevalier X. Long-term experience with hylan GF-20 in the treatment of knee osteoarthritis. Expert Opin Pharmacother. 2008;9:1797-1804. doi: 10.1517/14656566.9.10.1797.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>McCourt P.A. How does the hyaluronan scrap-yard operate? Matrix Biol. 1999;18:427-432. doi: 10.1016/S0945-053X(99)00045-1.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Frenkel J.S. The role of hyaluronan in wound healing. Int Wound J. 2014;11:159-163. doi: 10.1111/j.1742-481X.2012.01057.x.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Litwiniuk M., Krejner A., Speyrer M.S., Gauto A.R., Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28:78-88. Available from: https://www.hmpgloballearningnetwork.com/site/wounds/article/hyaluronic-acid-inflammation-and-tissue-regeneration.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Liang J., Jiang D., Noble P.W. Hyaluronan as a therapeutic target in human diseases. Adv Drug Deliv Rev. 2016;97:186-203. doi: 10.1016/j.addr.2015.10.017.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Holmes M.W.A., Bayliss M.T., Muir H. Hyaluronic acid in human articular cartilage. Age-related changes in content and size. Biochem J. 1988;250:435-441. doi: 10.1042/bj2500435.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Gupta R.C., Doss R.B., Lall R., Srivastava A., Sinha A. Nutraceuticals in arthritis. In: Gupta R.C., Srivastava A., Lall R. (eds.) Nutraceuticals in Veterinary Medicine. Cham: Springer Nature; 2019. p. 365-381.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Jadin L., Bookbinder L.H., Frost G.I. A comprehensive model of hyaluronan turnover in the mouse. Matrix Biol. 2012;31(2):81-89. doi: 10.1016/j.matbio.2011.11.002.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Heldin P., Basu K., Olofsson B., Porsch H., Kozlova I., Kahata K. Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer. J Biochem. 2013;154(5):395-408. doi: 10.1093/jb/mvt085.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Laurent U.B., Dahl L.B., Reed R.K. Catabolism of hyaluronan in rabbit skin takes place locally, in lymph nodes and liver. Exp Physiol. 1991;76(5):695-703. doi: 10.1113/expphysiol.1991.sp003536.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Lesley J., Hyman R. CD44 structure and function. Front Biosci. 1998;3:616-630. doi: 10.2741/a306.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Caires R., Luis E., Taberner F.J., Fernandez-Ballester G., Ferrer-Montiel A., Balazs E.A. et al. Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain. Nat Commun. 2015;6:8095. doi: 10.1038/ncomms9095.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Ferrari L.F., Khomula E.V., Araldi D., Levine J.D. CD44 signaling mediates high molecular weight hyaluronan-induced Antihyperalgesia. J Neurosci. 2018;38(2): 308-321. doi: 10.1523/jneurosci.2695-17.2017.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Bonet I.J.M., Araldi D., Khomula E.V., Bogen O., Green P.G., Levine J.D. Mechanisms mediating high-molecular-weight hyaluronan-induced Antihyperalgesia. J Neurosci. 2020;40(34):6477-6488. doi: 10.1523/jneurosci.0166-20.2020.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Machado V., Morais M., Medeiros R. Hyaluronic Acid-Based Nanomaterials Applied to Cancer: Where Are We Now? Pharmaceutics. 2022;14(10).2092. doi: 10.3390/pharmaceutics14102092.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Noble P.W. Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol. 2002;21(1):25-29. doi:10.1016/s0945-053x(01)00184-6.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Pahwa R., Nallasamy P., Jialal I. Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx. J Diabetes Complications. 2016;30(4):563-572. doi: 10.1016/j.jdiacomp.2016.01.014.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Moreland L.W. Intra-articular hyaluronan. (hyaluronic acid) and hyalans for the treatment of osteoarthritis: mechanism of action. Arthr Res Ther. 2003;5(2):54-67. doi: 10.1186/ar623.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Chernos M., Grecov D., Kwok E., Bebe S., Babsola O., Anastassiades T. Rheological study of hyaluronic acid derivatives. Biomed Eng Lett. 2017;7(1):17-24. doi: 10.1007/s13534-017-0010-y.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>George E. Intra-articular hyaluronan treatment for osteoarthritis. Ann Rheum Dis. 1998;57:637-40. doi: 10.1136/ard.57.11.637.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Bagga H., Burkhardt D., Sambrook P., March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006; 33(5):946-950. Available from: https://www.jrheum.org/content/33/5/946.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Yasuda T. Progress of research in osteoarthritis: pharmacological effects of hyaluronan. Clin Calcium. 2009;19:1644-1652.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Bothner H., Wik O. Rheology of hyaluronate. Acta Otolaryngol. 1987;104(S442):25-30. doi: 10.3109/00016488709102834.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Wang C.T., Lin Y.T., Chiang B.L., Lin Y.H., Hou S.M. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthr Cartilage. 2006;14(12):1237-1247. doi: 10.1016/j.joca.2006.05.009.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Ghosh P., Guidolin D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent? Semin Arthritis Rheum. 2002;32(1):10-37. doi: 10.1053/sarh.2002.33720.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Yasuda T. Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages. Tohoku J Exp Med. 2010;220(3):229-235. doi: 10.1620/tjem.220.229.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Sasaki A., Sasaki K., Konttinen Y.T., Santavirta S., Takahara M. et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. Tohoku J Exp Med. 2004;204(2):99-107. doi: 10.1620/tjem.204.99.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Gupta R.C., Lall R., Srivastava A., Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. doi: 10.3389/fvets.2019.00192.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Migliore A., Procopio S. Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab. 2015;12(1):31-33. doi: 10.11138/ccmbm/2015.12.1.031.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Xing F., Zhou C., Hui D., Du C., Wu L., Wang L. et al. Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions. Nanotechnology Reviews. 2020;9:1059-1079. doi: 10.1515/ntrev-2020-0084.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Balazs E.A., Denlinger J.L. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol. 1993;39:3-9.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Страхов М.А., Алексеева Л.И., Маремкулов К.К. Низкомолекулярные гиалуронаты: биологическое действие, эффективность, безопасность и клинический опыт лечения болевых синдромов опорно-двигательного аппарата (обзор литературы и клинические наблюдения). Современная ревматология. 2023;17(1): 93-100. doi: 10.14412/1996-7012-2023-1-93-100. Strakhov M.A., Alekseeva L.I., Maremkulov K.K. Low molecular weight hyaluronates: biological action, efficacy, safety and clinical experience in the treatment of musculoskeletal pain syndromes (literature review and clinical observations). Modern Rheumatology Journal. 2023;17(1):93-100. (In Russian). doi: 10.14412/1996-7012-2023-1-93-100.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Ilyin S.O., Kulichikhin V.G., Malkin A.Y. The rheological characterisation of typical injection implants based on hyaluronic acid for contour correction. Rheol. Acta. 2016;55:223-233. doi: 10.1007/s00397-016-0913-z.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Иванов П.Л., Хабаров В.Н. Биомедицинское применение гиалуроновой кислоты и её химически модифицированных производных. Москва: ГЭОТАР-Медиа; 2020. 288 с.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Migliore A., Integlia D., Pompilio G., Di Giuseppe F., Aru C., Brown T. Cost-effectiveness and budget impact analysis of viscosupplementation with hylan G-F 20 for knee and hip osteoarthritis. Clinicoecon Outcomes Res. 2019;11:453-464. doi: 10.2147/CEOR.S194669.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Mordin M., Parrish W., Masaquel C., Bisson B., Copley-Merriman C. Intra-articular hyaluronic acid for osteoarthritis of the knee in the united states: a systematic review of economic evaluations. Clin Med Insights Arthritis Musculoskelet Disord. 2021;14:11795441211047284. doi: 10.1177/11795441211047284.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Zhu K.Y., Acuña A.J., Samuel L.T., Grits D., Kamath A.F. Hyaluronic acid injections for knee osteoarthritis: has utilization among medicare beneficiaries changed between 2012 and 2018? J Bone Joint Surg Am. 2022;104(10):e43. doi: 10.2106.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Dysart S., Utkina K., Stong L., Nelson W., Sacks N., Healey B. et al. Insights from real-world analysis of treatment patterns in patients with newly diagnosed knee osteoarthritis. Am Health Drug Benefits. 2021;14(2) :56-62. Available from: https://https.ncbi.nlm.nih.gov/pmc/articles/PMC8244737/.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Schmajuk G., Bozic K.J., Yazdany J. Using Medicare data to understand low-value health care: the case of intra-articular hyaluronic acid injections. JAMA Intern Med. 2014;174:1702-1704. doi: 10.1001/jamainternmed.2014.3926.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Bhandari M., Bannuru R.R., Babins E.M., Martel- Pelletier J., Khan M., Raynauld J.P. et al. Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective. Ther Adv Musculoskelet Dis. 2017;9(9):231-246. doi: 10.1177/1759720X17729641.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Bruyère O., Honvo G., Veronese N., Arden N.K., Branco J., Curtis E.M. et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337-350. doi: 10.1016/j.semarthrit.2019.04.008.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Варонько И.А. Место препаратов гиалуроновой кислоты в лечении остеоартрита. Медицинские новости. 2018; 2:24-28. Varonka I.A. The role of hyaluronic acid preparations in the treatment of osteoarthritis. Meditsinskie novosti. 2018; 2:24-28. (In Russian).</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Экспертный совет. О применении гиалуроновой кислоты для локальной инъекционной терапии патологий верхней, нижней конечности, заболеваний спины и позвоночника: пострелиз. РМЖ. Медицинское обозрение. 2023;7(4):232-233. Available from: https://www.rusmedreview.com/archive/ khirurgiya-urologiya-4-2023. Expert Council. The use of hyaluronic acid for local injection therapy in pathologies of upper and lower extremities and spinal disorders: post-release. Russian Medical Inquiry. 2023;7(4):232-233. (In Russian). Available from: https://www.rusmedreview.com/archive/khirurgiya-urologiya-4-2023/.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Migliore A., Procopio S. Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab. 2015;12(1):31-33. doi: 10.11138/ccmbm/2015.12.1.031.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Weiss С. Viscosupplementation in the olderpatient with osteoarthritis. Operative Techniques in Orthopaedics. 2002;12(2):124-130. doi: 10.1053/otor.2002.36174.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Qiao X., Yan L., Feng Y., Li X., Zhang K., Lv Z. et al. Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis. BMC Musculoskelet Disord. 2023;24(1):926. doi: 10.1186/s12891-023-06925-6.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Safali S., Ertaş E.S., Özdemir A., Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25(1):164. doi: 10.1186/s12891-024-07200-y.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Pereira T.V., Jüni P., Saadat P., Xing D., Yao L., Bobos P. et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. 2022;378: e069722. doi: 10.1136/bmj-2022-069722.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Ferkel E., Manjoo A., Martins D., Bhandari M., Sethi P., Nicholls M. Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage. 2023;14(4):424-432. doi: 10.1177/19476035231154530.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Migliore A., Maheu E., Saccone L., de Campos G.C., Alekseeva L., Chevalier X., Conrozier T. et al. What We Should Expect from an Innovative Intra-Articular Hyaluronic Acid Product: Expert Opinion Based on a Comprehensive Review of the Literature. J Clin. Med. 2023;12(23):7422. doi: 10.3390/jcm12237422.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Wu B., Li Y., Liu Y. Efficacy of intra-articular hyaluronic acid injections in hip osteoarthritis: a meta-analysis of randomized controlled trials. Oncotarget. 2017;8(49): 86865-86876. doi: 10.18632/oncotarget.20995.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>De Lucia O., Pierannunzii L.M., Pregnolato F., Verduci E., Crotti C., Valcamonica E. Et al. Effectiveness and Tolerability of Repeated Courses of Viscosupplementation in Symptomatic Hip Osteoarthritis: A Retrospective Observational Cohort Study of High Molecular Weight vs. Medium Molecular Weight Hyaluronic Acid vs. No Viscosupplementation. Front Pharmacol. 2019; 10:1007. doi: 10.3389/fphar.2019.01007.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Clementi D., D’Ambrosi R., Bertocco P., Bucci M.S., Cardile C., Ragni P. et al. Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study. Eur J Orthop Surg Traumatol. 2018;28(5):915-922. doi: 10.1007/s00590-017-2083-9.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Familiari F., Ammendolia A., Rupp M.C., Russo R., Pujia A., Montalcini T. et al. Efficacy of intra-articular injections of hyaluronic acid in patients with glenohumeral joint osteoarthritis: A systematic review and meta-analysis. J Orthop Res. 2023;41(11): 2345-2358. doi: 10.1002/jor.25648.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Younger A.S.E., Penner M., Wing K., Veljkovic A., Nacht J., Wang Z. et al. Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: A Prospective, Single-Arm Cohort Study. J Foot Ankle Surg. 2019;58(3): 514-518. doi: 10.1053/j.jfas.2018.10.003.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Murphy E.P., Curtin M., McGoldrick N.P., Thong G., Kearns S.R. Prospective Evaluation of Intra-Articular Sodium Hyaluronate Injection in the Ankle. J Foot Ankle Surg. 2017;56(2):327-331. doi: 10.1053/j.jfas.2016.09.017.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Kroon F.P.B., Rubio R., Schoones J.W., Kloppenburg M. Intra-Articular Therapies in the Treatment of Hand Osteoarthritis: A Systematic Literature Review. Drugs Aging. 2016;33(2):119-133. doi: 10.1007/s40266-015-0330-5.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Riley N., Vella-Baldacchino M., Thurley N., Hopewell S., Carr A.J., Dean B.J.F. Injection therapy for base of thumb osteoarthritis: a systematic review and meta-analysis. BMJ Open. 2019;9(9):e027507. doi: 10.1136/bmjopen-2018-027507.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Qiao X., Yan L., Feng Y., Li X., Zhang K., Lv Z. et al. Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis. BMC Musculoskelet Disord. 2023;24(1):926. doi: 10.1186/s12891-023-06925-6.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Khan M., Shanmugaraj A., Prada C., Patel A., Babins E., Bhandari M. The Role of Hyaluronic Acid for Soft Tissue Indications: A Systematic Review and Meta-Analysis. Sports Health. 2023;15(1):86-96. doi: 10.1177/19417381211073316.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Fogli M., Giordan N., Mazzoni G. Efficacy and safety of hyaluronic acid (500-730kDa) Ultrasound-guided injections on painful tendinopathies: a prospective, open label, clinical study. Muscle Ligaments Tendons J. 2017;7(2):388-395. doi: 10.11138/mltj/2017.7.2.388.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Agostini F., de Sire A., Paoloni M., Finamore N., Ammendolia A., Mangone M. Effects of hyaluronic acid injections on pain and functioning in patients affected by tendinopathies: A narrative review. J Back Musculoskelet Rehabil. 2022;35(5):949-961. doi: 10.3233/BMR-210309.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Crimaldi S., Liguori S., Tamburrino P., Moretti A., Paoletta M., Toro G. et al. The Role of Hyaluronic Acid in Sport-Related Tendinopathies: A Narrative Review. Medicina. 2021;57(10):1088. doi: 10.3390/medicina57101088.</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Shivam B., Balgovind S.R., Bishwa B.N., Anil R., Arghya K.C., Divyansh S. Efficacy of hyaluronic acid in rotator cuff pathology compared to other available treatment modalities: A Systematic Review and meta-analysis. Journal of Orthopaedic Reports. 2023;2(3):100157. doi: 10.1016/j.jorep.2023.100157.</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Zhi F., Cai F., Zhang W., Xiong L., Hu J., Lin X. Clinical efficacy of different shoulder joint drug injections for rotator cuff injuries: A network meta-analysis. Medicine (Baltimore). 2022;101(39):e30659. doi: 10.1097/MD.0000000000030659.</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Papalia R., Tecame A., Vadalà G., Russo F., Perna M., Papalia G. et al. The use of hyaluronic acid in the treatment of shoulder capsulitis: a systematic review. J Biol Regul Homeost Agents. 2017;31(4 Suppl 2):23-32. Available from: https://www.biolifesas.org/EN/Y2017/V31/I4(S2)/23.</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Jang M.H., Lee C.H., Shin Y.I., Kim S.Y., Huh S.C. Effect of Intra-articular Hyaluronic Acid Injection on Hemiplegic Shoulder Pain After Stroke. Ann Rehabil Med. 2016;40(5):835-844. doi: 10.5535/arm.2016.40.5.835.</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Yang X., Liang W., Li J., Liu P. A meta-analysis and systematic review of the therapeutic effects of arthroscopy combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis. Ann Palliat Med. 2021;10(9):9859-9869. doi: 10.21037/apm-21-2145.</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>Kumai T., Samoto N., Hasegawa A., Noguchi H., Shiranita A., Shiraishi M. et al. Short-term efficacy and safety of hyaluronic acid injection for plantar fasciopathy. Knee Surg Sports Traumatol Arthrosc. 2018;26(3):903-911. doi: 10.1007/s00167-017-4467-0.</mixed-citation></ref><ref id="B84"><label>84.</label><mixed-citation>Costa, F.R., Costa Marques M.R., Costa V.C., Santos G.S., Martins R.A., Santos M.В.S. et al. Intra-Articular Hyaluronic Acid in Osteoarthritis and Tendinopathies: Molecular and Clinical Approaches. Biomedicines. 2023;11(4):1061. doi: 10.3390/biomedicines11041061.</mixed-citation></ref></ref-list></back></article>
