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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17560</article-id><article-id pub-id-type="doi">10.17816/2311-2905-17560</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case Reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Случаи из практики</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Case Reports</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Salvage of a comminuted proximal tibial polymicrobial infected non-union with antibiotic loaded bio-composite and intramedullary nailing: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение инфицированного несросшегося оскольчатого перелома проксимального отдела большеберцовой кости методом интрамедуллярного остеосинтеза в сочетании с биокомпозитом, импрегнированным антибиотиком: клинический случай</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3808-6116</contrib-id><name-alternatives><name xml:lang="en"><surname>Stanley</surname><given-names>Ciaran</given-names></name><name xml:lang="ru"><surname>Стэнли</surname><given-names>Киаран</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="IE">Ireland</country></address><email>ciaranstanley@rcsi.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7783-3130</contrib-id><name-alternatives><name xml:lang="en"><surname>Woods</surname><given-names>Robert</given-names></name><name xml:lang="ru"><surname>Вудс</surname><given-names>Роберт</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="IE">Ireland</country></address><email>robjnwoods@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9882-7422</contrib-id><name-alternatives><name xml:lang="en"><surname>Hassan</surname><given-names>Mohammed</given-names></name><name xml:lang="ru"><surname>Хассан</surname><given-names>Мохаммед</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="IE">Ireland</country></address><email>mohhashim1988@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4051-3882</contrib-id><name-alternatives><name xml:lang="en"><surname>McInerney</surname><given-names>Niall</given-names></name><name xml:lang="ru"><surname>МакИнерни</surname><given-names>Ниалл</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="IE">Ireland</country></address><email>nmac@ymail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0970-3274</contrib-id><name-alternatives><name xml:lang="en"><surname>Sheridan</surname><given-names>Gerard</given-names></name><name xml:lang="ru"><surname>Шеридан</surname><given-names>Джерард</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="IE">Ireland</country></address><email>sheridga@tcd.ie</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">University Hospital Galway</institution></aff><aff><institution xml:lang="ru">University Hospital Galway</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-09-30" publication-format="electronic"><day>30</day><month>09</month><year>2024</year></pub-date><volume>30</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>112</fpage><lpage>119</lpage><history><date date-type="received" iso-8601-date="2024-05-29"><day>29</day><month>05</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-08-20"><day>20</day><month>08</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2024,</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/17560">https://journal.rniito.org/jour/article/view/17560</self-uri><abstract xml:lang="en"><p><bold>Background. </bold>Management of open proximal metaphyseal fractures poses a significant challenge and is fraught with complications. These injuries are severe, often accompanied by extensive soft tissue and vascular damage, leading to high risks of infection and long-term disability.</p> <p><bold>Case presentation.</bold> A 72-year-old male was severely injured in a road traffic accident. Plain X-rays and CT angiogram identified a comminuted proximal tibial fracture with transection of the popliteal artery and vein. Initial emergency treatment included fasciotomies, external fixation, and vascular primary repair. On the 12<sup>th</sup> day of admission, the patient underwent open reduction and internal fixation (ORIF) with dual plate fixation using a two incision technique. A plastic surgeon performed skin grafting, harvested from the patient’s thigh, to allow closure of his fasciotomy wounds immediately following ORIF. Four weeks post-operatively, the patient developed a wound breakdown over the lateral fasciotomy site, exposing the metal plates with a small defect developing on the medial fasciotomy wound in tandem. The patient’s course was further complicated by persistent polymicrobial infections. Over 6 months of antibiotic regimes, operative intervention was ultimately required. All of the infected metal implants were removed, the non-union sites were aggressively debrided. The tibial canal was reamed to prepare for a tibial nailing. An antibiotic loaded bio-composite was then inserted through the non-union sites into the canal followed by an intramedullary nail. A blocking screw was used to address the procurvatum deformity in the sagittal plane. The patient currently shows signs of recovery, mobilizing over short distances, weight-bearing with assistive aids and with healing wounds and early signs of callus formation on recent CT scans and plain X-rays.</p> <p><bold>Conclusions. </bold>The management of complex tibial fractures with vascular involvement demands an aggressive multidisciplinary approach and continuous adaptability in treatment plans to address the evolving challenges of such severe injuries. This case exemplifies the utility of injectable antibiotic-loaded bio-composites in a limb-salvage setting and their ability to provide high doses of local antibiotics to an infection site which, in conjunction with appropriate stable fixation and systemic antibiotics, can aid in eradicating and treating fracture-related infections.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Актуальность. </bold>Лечение открытых переломов проксимального метаэпифиза большеберцовой кости сопровождается сложностями и чревато осложнениями. Эти тяжелые травмы часто сочетаются с обширным повреждением мягких тканей и сосудов, что приводит к высокому риску инфекции и долгосрочной инвалидизации.</p> <p><bold>Описание клинического наблюдения.</bold> В результате дорожно-транспортного происшествия 72-летний мужчина получил тяжелые травмы. Обзорная рентгенограмма и КТ-ангиограмма выявили оскольчатый перелом проксимального отдела большеберцовой кости с повреждением подколенной артерии и вены. Первичное неотложное лечение включало фасциотомию, внешнюю фиксацию и восстановление сосудов голени. На 12-й день госпитализации пациенту были выполнены открытая репозиция и внутренняя фиксация (ORIF) перелома большеберцовой кости двумя пластинами. Для закрытия раны голени после фасциотомии была выполнена пересадка кожи с бедра. Через четыре недели после операции у пациента произошло расхождение краев ран голени над местом фасциотомий: по латеральной стороне — с обнажением металлической пластины; по медиальной стороне — с небольшим дефектом мягких тканей. Течение заболевания у пациента усугубилось персистирующей полимикробной инфекцией. Неэффективность консервативного антибактериального лечения в течение более 6 мес. в конечном итоге привела к хирургическому вмешательству. Все инфицированные металлические имплантаты были удалены, несросшиеся участки костей были очищены. Костномозговой канал большеберцовой кости был рассверлен для установки интрамедуллярного стержня. Через участки костных дефектов в области несращения большеберцовой кости в канал был введен биокомпозит с антибиотиком, затем установлен интрамедуллярный стержень. Для устранения антекурвационной деформации большеберцовой кости был использован отклоняющий винт. В настоящее время у пациента наблюдаются признаки выздоровления, он может передвигаться на короткие расстояния, также у него наблюдается заживление ран и визуализируются ранние признаки образования мозоли на КТ-сканах и рентгенограммах.</p> <p><bold>Заключение.</bold> Лечение сложных переломов большеберцовой кости с вовлечением сосудов требует агрессивного междисциплинарного подхода и постоянной адаптации планов лечения для решения меняющихся проблем при таких тяжелых травмах. Этот случай иллюстрирует полезность применения инъекционных биокомпозитов с антибиотиками при спасении конечности. Их способность обеспечивать высокие локальные дозы антибиотиков в месте инфекции в сочетании со стабильной фиксацией и системными антибиотиками помогает достичь успеха при лечении инфекций, связанных с переломом.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>comminuted tibial fractures</kwd><kwd>infected non-union</kwd><kwd>intramedullary nailing</kwd><kwd>antibiotic loaded bio-composite</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>оскольчатый перелом большеберцовой кости</kwd><kwd>инфекционные осложнения перелома</kwd><kwd>интрамедуллярный остеосинтез</kwd><kwd>импрегнированный антибиотиком биокомпозит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Dvorak J.E., Lasinski A.M., Romeo N.M., Hirschfeld A., Claridge J.A. Fracture related infection and sepsis in orthopedic trauma: A review. 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