Traumatology and Orthopedics of RussiaTraumatology and Orthopedics of RussiaТравматология и ортопедия России2311-29052542-0933Vreden National Medical Research Center of Traumatology and Orthopedics15110.21823/2311-2905-151ReviewsОбзорыReviewsUnknownNeuroendocrinal regulation of bone metabolism in osteoarthritis of large joints (review)Нейроэндокринная регуляция костного метаболизма при остеоартрозе крупных суставов (обзор литературы)LychkovaA. E.ЛычковаА. Э.
Russian Federation
ShirokovaL. Y.ШироковаЛ. Ю.
Russian Federation
KryukovaE. V.КрюковаЕ. В.
Russian Federation
Moscow Clinical Research Center of Moscow Health DepartmentГБУЗ «Московский клинический научно-практический центр» Департамента здравоохранения г. МосквыYaroslavl State Medical UniversityГБОУ ВПО «Ярославский государственный медицинский университет» Минздрава РоссииVologda Regional Clinic HospitalБУЗ ВО «Вологодская областная клиническая больница»1210201521310811512092016Copyright ©; 2015,Copyright ©; 2015,2015https://journal.rniito.org/jour/article/view/151

The regulation of bone metabolism by adrenergic, cholinergic and endocrine transmitters in osteoarthritis is reviewed. Regulatory effects of α- and β-receptor mechanisms of norepinephrine, M- and N-receptors of acetylcholine, glucocorticosteroids, PTH and peptidergic systems in the bone remodeling process are characterized that can serve as a basis for the development of promising therapies osteoarthritis.

В обзоре литературы рассмотрены вопросы периферической регуляции адренергическими, холинергическими и эндокринными трансмиттерами костного обмена при остеоартрозе. Охарактеризованы α- и β-рецепторные механизмы регуляторного воздействия норадреналина, М- и N-рецепторов ацетилхолина, глюкокортикостероидов, паратгормона и пептидергической системы на процессы ремоделирования костной ткани, что может послужить основой для разработки перспективных методов лечения остеоартроза.

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