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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">123</article-id><article-id pub-id-type="doi">10.21823/2311-2905-123</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>FOR PRACTICIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Systemic toxisity of local anesthethics during regional anesthesia in orthopedics and traumatology</article-title><trans-title-group xml:lang="ru"><trans-title>Системная токсичность местных анестетиков при регионарной анестезии в ортопедии и травматологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Koryachkin</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Корячкин</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vakoryachkin@rniito.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chupris</surname><given-names>V. G.</given-names></name><name xml:lang="ru"><surname>Чуприс</surname><given-names>В. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Cherny</surname><given-names>A. Z.</given-names></name><name xml:lang="ru"><surname>Черный</surname><given-names>А. Ж.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kasarin</surname><given-names>V. S.</given-names></name><name xml:lang="ru"><surname>Казарин</surname><given-names>В. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lis’Kov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Лиськов</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malevich</surname><given-names>G. M.</given-names></name><name xml:lang="ru"><surname>Малевич</surname><given-names>Г. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maltsev</surname><given-names>M. P.</given-names></name><name xml:lang="ru"><surname>Мальцев</surname><given-names>М. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Vreden Russian Research Institute of Traumatology and Orthopedics</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-04-12" publication-format="electronic"><day>12</day><month>04</month><year>2015</year></pub-date><volume>21</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>129</fpage><lpage>135</lpage><history><date date-type="received" iso-8601-date="2016-09-12"><day>12</day><month>09</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015,</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015,</copyright-statement><copyright-year>2015</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/123">https://journal.rniito.org/jour/article/view/123</self-uri><abstract xml:lang="en"><p>There are cases of accidental intravascular injection of local anesthetic when performing regional anesthesia. The frequency of this complication was 0.28 per 1,000. We describe the clinical manifestations and the basic principles of the treatment of local anesthetics systemic toxicity. Discussed in detail the mechanism of action of fat emulsion and the protocol of lipid resuscitation Accidental intravascular injection of local anesthetics. The mechanism of action of fat emulsion and the protocol of lipidrescue accidental intravascular injection of local anesthetics was discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены случаи непреднамеренного внутрисосудистого введения растворов местных анестетиков при выполнении регионарной анестезии. Частота этого осложнения составила 0,28 на 1000. Описаны клинические проявления и основные принципы интенсивной терапии системной токсичности местных анестетиков. Подробно освещены механизм действия жировой эмульсии и протокол проведения липидной реанимации при непреднамеренном внутрисосудистом введении местных анестетиков.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>системная токсичность местных анестетиков</kwd><kwd>липидные эмульсии</kwd><kwd>липидная реанимация</kwd><kwd>systemic toxicity of local anesthetics</kwd><kwd>lipid emulsion</kwd><kwd>lipid rescue</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Корячкин В.А. Нейроаксиальные блокады. СПб.: ЭЛБИ-СПб; 2013. 544 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Корячкин В.А., Страшнов В.И. Анестезия и интенсивная терапия. СПб.; 2004. 465 с.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Корячкин В.А., Эмануэль В.Л., Страшнов В.И. Диагностика в анестезиологии и интенсивной терапии. 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