<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Traumatology and Orthopedics of Russia</journal-id><journal-title-group><journal-title xml:lang="en">Traumatology and Orthopedics of Russia</journal-title><trans-title-group xml:lang="ru"><trans-title>Травматология и ортопедия России</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2311-2905</issn><issn publication-format="electronic">2542-0933</issn><publisher><publisher-name xml:lang="en">Vreden National Medical Research Center of Traumatology and Orthopedics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">122</article-id><article-id pub-id-type="doi">10.21823/2311-2905-2015-0-1-116-128</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="zh"><subject>Reviews</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern aspects of diagnostic and surgical treatment of patients with hip periprosthetic infection (review)</article-title><trans-title-group xml:lang="ru"><trans-title>Современные аспекты диагностики и хирургического лечения пациентов с перипротезной инфекцией тазобедренного сустава (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pavlov</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Павлов</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>pavlovdoc@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sadovoy</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Садовой</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prokhorenko</surname><given-names>V. M.</given-names></name><name xml:lang="ru"><surname>Прохоренко</surname><given-names>В. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tsivyan Novosibirsk Research Institute of Traumatology and Ortopaedics</institution></aff><aff><institution xml:lang="ru">ФГБУ «Новосибирский научно-исследовательский институт травматологии и ортопедии им. Я.Л. Цивьяна» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Tsivian Novosibirsk Scientific Research Institute of Traumatology and Ortopaedics</institution></aff><aff><institution xml:lang="ru">ФГБУ «Новосибирский научно-исследовательский институт травматологии и ортопедии им. Я.Л. Цивьяна» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-04-12" publication-format="electronic"><day>12</day><month>04</month><year>2015</year></pub-date><volume>21</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>116</fpage><lpage>128</lpage><history><date date-type="received" iso-8601-date="2016-09-12"><day>12</day><month>09</month><year>2016</year></date></history><permissions><copyright-year>2015</copyright-year><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journal.rniito.org/jour/article/view/122">https://journal.rniito.org/jour/article/view/122</self-uri><abstract xml:lang="en"><p>Hip replacement is widespread surgical procedure in orthopedic surgery. Nether the less, the main and most costly problems in replacement of large joints with socially significant losses are infectious complications. The aim of this review is to analyze available data dedicated to infectious complications in orthopedy and to extract basic principles of diagnostics and treatment of the hip joint implant infection. It could be stated that early diagnostics and precise identification of causative agent, including evaluation of the microbiological, clinical, diagnostic imaging, immunological, histological and biochemical parameters, and also an adequate to the collected diagnostic data choice of surgical tactics and antibiotic treatment are the important components of successful treatment of periprosthetic infection.</p></abstract><trans-abstract xml:lang="ru"><p>Эндопротезирование тазобедренного сустава получило широкое распространение в ортопедической хирургии. Тем не менее одной из основных и наиболее затратных проблем эндопротезирования крупных суставов с социально значимыми потерями являются инфекционные осложнения. Целью настоящего обзора является систематизация информации по данной проблеме для определения основных принципов диагностики и лечения инфекции протезированного тазобедренного сустава. Опираясь на литературные сведения, можно говорить о том, что ранняя комплексная диагностика и точная идентификация возбудителя, включающая в себя оценку микробиологических, клинических, рентгенологических, иммунологических, гистологических, биохимических параметров, а также адекватный результатам диагностического поиска выбор хирургической тактики и антибиотикотерапии являются важными составляющими успешного лечения перипротезной инфекции.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндопротезирование тазобедренного сустава</kwd><kwd>перипротезная инфекция</kwd><kwd>диагностика</kwd><kwd>этиология</kwd><kwd>хирургическое лечение</kwd><kwd>periprosthetic infection</kwd><kwd>diagnosis</kwd><kwd>etiology</kwd><kwd>surgical treatment</kwd><kwd>hip joint</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Божкова С.А, Петрова Т.М., Мирзоев Н.Э. Этиологическая структура и антибиотикорезистентность ведущих возбудителей парапротезной инфекции в стационаре травматолого-ортопедического профиля. В кн.: Рациональная фармакотерапия и клиническая фармакология: сборник научных материалов Конгресса. СПб.; 2010. С. 49-52.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Гольдина И.А., Павлов В.В., Прохоренко В.М. Клинико-морфологические особенности коксартроза, ассоциированного с Chlamydia Trachomatis. Бюллетень СО РАМН. 2007; (124):43-46.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Материалы международной согласительной конференции по перипротезной инфекции: пер. с англ. под общ. ред. Р.М. Тихилова. СПб.; 2014. 355 с.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Пат. 2204832 РФ. МПК, G01N33/48 Способ прогнозирования риска развития инфекционных осложнений. Павлов В.В., Гольдина И.А., Прохоренко В.М., Гайдуль К.В., Козлов В.А., Фомичев Н.Г. Заявитель и патентообладатель ФГБУ НИИТО им. Я.Л. Цивьяна. (RU) № 2001104752, заявлен 19.02.2001; опубликован 20.05. 2003. Бюлл. № 14.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Пичхадзе И.М., Жадин А.В., Кузьменков K.A., Цискаришвили А.В., Данелия Л.М. Лечение больных с гнойно-воспалительными осложнениями после эндопротезирования тазобедренного сустава. Вестн. травматологии и ортопедии им. Н.Н. Приорова. 2009; (3):45-50.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Прохоренко В.М., Павлов В.В. Инфекционные осложнения при эндопротезировании тазобедренного сустава. Новосибирск: Наука; 2010. 179 с.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Савельев В.С. Российские национальные рекомендации по классификации характера инфекции по уровням поражения. Под ред. В.С. Савельева. М.; 2009. 92 с.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Фадеев С.Б. Хирургическая инфекция мягких тканей второго уровня, особенности этиотропной терапии [автореф. дис. д.м.н.]. Оренбург; 2010.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Ata A., Lee J., Bestle S.L., Desemone J., Stain S.C. Postoperative hyperglycemia and surgical site infection in general surgery patients. Arch Surg. 2010; 145(9): 858-864. doi: 10.1001/archsurg.2010.179.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Berbari E.F., Osmon D.R., Carr A., Hanssen A.D., Baddour L.M., Greene D. et al. Dental procedures as risk factors for prosthetic hip or knee infection: a hospital-based prospective case-control study. Clin. Infect. Dis. 2010; 50(1):8-16. doi: 10.1086/648676.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bergh C., Fenstad A.M., Furnes O., Garellick G., Havelin L.I., Overgaard S. et al. Increased risk of revision in patients with non-traumatic femoral head necrosis. Acta Orthop. 2014; 85(1):11-7. doi: 10.3109/17453674.2013.874927.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Bogut A., Niedzwiadek J., Strzelec-Nowak D., Blacha J., Mazurkiewicz T., Marczynski W., Koziol-Montewka M. Infectious prosthetic hip joint loosening: bacterial species involved in its aetiology and their antibiotic resistance profiles against antibiotics recommended for the therapy of implant-associated infections. New Microbiol. 2014; 37(2):209-218.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Bourne R.B., Hunter G.A., Rorabeck C.H., Macnab J.J. A six year follow-up infected total hip arthroplasty managed by Girdlestone’s arthroplasty. J Bone Joint Surg. 1996; 66-B:340-343.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Buechel F.F., Femino F.P., D'Alessio J. Primary exchange revision arthroplasty for infected total knee replacement: a long-term study. Am J Orthop. 2004; 33:190.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Cazanave C., Greenwood-Quaintance K.E., Hanssen A.D., Karau M.J., Schmidt S.M., Gomez Urena E.O. et al. Rapid molecular microbiologic diagnosis of prosthetic joint infection. J Clin Microbiol. 2013; 51(7):2280-2287. doi: 10.1128/JCM.00335-13.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Coelho-Prabhu N., Oxentenko A.S., Osmon D.R., Baron T.H., Hanssen A.D., Wilson W.R. et al. Increased risk of prosthetic joint infection associated with esophago-gastroduodenoscopy with biopsy. Acta Orthop. 2013;84(1): 82-86. doi: 10.3109/17453674.2013.769079.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Coventry M.B. Treatment of infections occurring in total hip surgery. Orthop Clin North Am. 1975; 6(4): 991-1003.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Crockarell J.R., Hanssen A.D., Osmon D.R., Morrey B.F Treatment of infection with debridement and retention of the components following hip arthroplasty. J Bone Joint Surg. 1998; 80-A:1306-1313.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Deirmengian C., Kardos K., Kilmartin P., Cameron A., Schiller K., Parvizi J. Combined measurement of synovial fluid α-defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection. J Bone Joint Surg Am. 2014;96(17): 1439-1445. doi: 10.2106/JBJS.M.01316.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Deleanu B., Prejbeanu R., Vermesan D., Haragus H., Icma I., Predescu V. Acute abdominal complications following hip surgery. Chirurgia (Bucur). 2014; 109(2):218-222.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Della Valle C., Parvizi J., Bauer T.W., Di Cesare P.E. Evans R.P Segreti J. et al. Diagnosis of periprosthetic joint infections of the hip and knee. J AAOS. 2010; 18(12):760-770.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Drago L., Vassena C., Dozio E., Corsi M.M., De Vecchi E., Mattina R., Romano C. Procalcitonin, C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1 as markers of postoperative orthopaedic joint prosthesis infections. Int J Immunopathol Pharmacol. 2011; 24(2):433-440.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Drancourt M., Stein A., Argenson J.N., Zannier A., Curvale G., Raoult D. Oral rifampicin plus ofloxacin for treatment of Staphylococcus - infected orthopaedic implants. Antimicrob Agents Chemother. 1993; 37:305-313.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>El Masri F., Kerboull L., Kerboull M., Courpied J.P., Hamadouche M. Is the so-called 'French paradox' a reality?: long-term survival and migration of the Charnley-Kerboull stem cemented line-to-line. J Bone Joint Surg Br. 2010; 92(3):342-348.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Fevang B.T., Lie S.A., Havelin L.I., Engesaeter L.B., Furnes O. Improved results of primary total hip replacement. Acta Orthop. 2010; 81(6):649-659.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Fitzgerald M.D., Robert H. Infected total hip arthroplasty: diagnosis and treatment. J. AAOS. 1995; (3):249-262.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Gollwitzer H., Diehl P., Gerdesmeyer L., Mittelmeier W. Diagnostic strategies in cases of suspected periprosthetic infection of the knee. A review of the literature and current recommendations. Orthopedics. 2006; 35(9):904, 906-908, 910-916.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Glehr M., Friesenbichler J., Hofmann G., Bernhardt G.A., Zacherl M., Avian A. et al. Novel biomarkers to detect infection in revision hip and knee arthroplasties. Clin Orthop Relat Res. 2013; 471(8): 2621-2628. doi: 10.1007/ s11999-013-2998-3.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Greidanus N.V., Masri B.A., Garbuz D.S., Wilson S.D., McAlinden M.G., Xu M., Duncan C.P Use of erythrocyte sedimentation rate and C-reactive protein level to diagnose infection before revision total knee arthroplasty: a prospective evaluation. J Bone Joint Surg Am. 2007; 89-A:1409-1416.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Gutowski C.J., Zmistowski B.M., Clyde C.T., Parvizi J. The economics of using prophylactic antibiotic-loaded bone cement in total knee replacement. Bone Joint J. 2014; 96-B(1):65-69. doi: 10.1302/0301-620X.96B1.31428.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Haddad F.S., Masri B.A., Campbell D., McGraw R.W., Beuchamp C.P., Duncan C.P. The PROSTALAC functional spacer in two-stage revision for infected knee replacements. prosthesis of antibiotic-loaded acrylic cement. J Bone Joint Surg. 2000; 82-B:807-812.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Hailer N.P., Garellick G., Karrholm J. Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register. Acta Orthop. 2010; 81(1): 34-41.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Horan T.C., Gaynes R.P., Martone W.J., Jarvis W.R., Emori T.G. CDC definitions of nosocomial surgical site infections, 1992; A modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992; 13:606-608.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Jonsson E.Ö., Johannesdottir H., Robertsson O., Mogensen B. Bacterial contamination of the wound during primary total hip and knee replacement. Median 13 years of follow-up of 90 replacements. Acta Orthop. 2014; 85(2):159-164. doi: 10.3109/17453674.2014.899848.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Jordan R.W., Smith N.A., Saithna A., Sprowson A.P., Foguet P. Sensitivities, specificities, and predictive values of microbiological culture techniques for the diagnosis of prosthetic joint infection. Biomed Res Int. 2014; 2014:180416. doi: 10.1155/2014/180416.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Kraay M.J., Goldberg V.M., Fitzgerald S.J., Salata M.J. Cementless two-staged total hip arthroplasty for deep periprosthetic infection. Clin Orthop. 2005; 441:243-249.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Kundu Z.S., Gupta V., Gogna P., Sangwan S.S. Partial-limb salvage after persistent infection in the distal femoral prosthesis: straight-plasty - a novel technique. J Coll Physicians Surg Pak. 2014; 24(3):213-215. doi: 03.2014/ JCPSP213215.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Leaper D., McBain A.J., Kramer A., Assadian O., Sanchez J.L., Lumio J., Kiernan M. Healthcare associated infection: novel strategies and antimicrobial implants to prevent surgical site infection. Ann R Coll Surg Engl. 2010; 92(6):453-458. doi: 10.1308/003588410X12699663905276.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Mäkelä K.T., Matilainen M., Pulkkinen P., Fenstad A.M., Havelin L.I., Engesaeter L. et al. Countrywise results of total hip replacement. An analysis of 438,733 hips based on the Nordic Arthroplasty Register Association database. Acta Orthop. 2014;(85()) 107-116. doi: 10.3109/17453674.2014.893498.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Miyamae Y., Inaba Y., Kobayashi N., Choe H., Yukizawa Y., Ike H., Saito T. Different diagnostic properties of C-reactive protein, real-time PCR, and histopathology of frozen and permanent sections in diagnosis of periprosthetic joint infection. Acta Orthop. 2013;84(6):524-529. doi: 10.3109/17453674.2013.862460.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Lachiewictz P.F., Rogers G.D., Thomason H.C. Aspiration of the joint before revision total hip arthroplasty: clinical and laboratory factors influencing attainment of a positive culture. J Bone Joint Surg Am. 1996; 78(5):749-754.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Larsen L.H., Lange J., Xu Y., Schonheyder H.C. Optimizing culture methods for diagnosis of prosthetic joint infections: a summary of modifications and improvements reported since 1995. J Med Microbiol. 2012; 61(Pt 3):309-316. doi: 10.1099/jmm.0.035303-0.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Parvizi J., Jacovides C., Antoci V., Ghanem E. Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme. J Bone Joint Surg Am. 2011; 93(24):2242-2248. doi: 10.2106/JBJS.J.01413.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Parvizi J., Jacovides C., Zmistowski B., Jung K.A. Definition of periprosthetic joint infection: Is there a consensus? Clin Orthop Relat Res. 2011; 469(11):3022-3030.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Pearson O.M., Lieberman D.E. The aging of Wolffs “law” ontogeny and responses to mechanical loading in cortical bone. Am J Phys Anthropol. 2004; Suppl. 39:63-99.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Peel T.N., Dowsey M.M., Daffy J.R., Stanley P.A., Choong P.F., Buising K.L. Risk factors for prosthetic hip and knee infections according to arthroplasty site. J Hosp Infect. 2011; 79(2):129-133. doi: 10.1016/j.jhin.2011.06.001.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Pedersen A.B., Svendsson J.E., Johnsen S.P., Riis A., Overgaard S. Risk factors for revision due to infection after primary total hip arthroplasty. A population-based study of 80,756 primary procedures in the Danish Hip Arthroplasty Registry. Acta Orthop. 2010; 81(5):542-547.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Phillips C.B. Incidence rates of dislocation, pulmonary embolism and deep infection during the first six months after elective total hip replacement. J Bone Joint Surg. 2003; 85-A (1):20-26.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Prokopetz J.Z., Losina E., Bliss R.L., Wright J., Baron J.A., Katz J.N. Risk factors for revision of primary total hip arthroplasty: a systematic review. BMC Musculoskelet Disord. 2012; 13:251. doi: 10.1186/1471-2474-13-251.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Reid N., Beesley J.E. Sectioning and cryosectioning for electron microscopy. Amsterdam: Elsevier; 1991. 322p.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Ravi B., Escott B., Shah P.S., Jenkinson R., Chahal J., Bogoch E., Kreder H., Hawker G. A systematic review and meta-analysis comparing complications following total joint arthroplasty for rheumatoid arthritis versus for osteoarthritis. Arthritis Rheum. 2012; 64(12):3839-3849. doi: 10.1002/art.37690.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Saccente M. Periprosthetic joint infections: a review for clinicians. Infect Dis Clin Pract. 1998; (7):431-441.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Schamalzried T.P., Amstutz H.C., Au M.K. Etiology of deep sepsis in total hip arthroplasty: the significance of hematogenous and recurrent infections. Clin Orthop Relat Res. 1992; 280: 200-207.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Schwotzer N., Wahl P., Fracheboud D., Gautier E., Chuard C. Optimal culture incubation time in orthopedic deviceassociated infections: a retrospective analysis of prolonged 14-day incubation. J Clin Microbiol. 2014; 52(1):61-66. doi: 10.1128/JCM.01766-13.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Schrama J.C., Espehaug B., Hallan G., Engesaeter L.B., Furnes O., Havelin L.I., Fevang B.T. Risk of revision for infection in primary total hip and knee arthroplasty in patients with rheumatoid arthritis compared with osteoarthritis: a prospective, population-based study on 108,786 hip and knee joint arthroplasties from the Norwegian Arthroplasty Register. Arthritis Care Res. (Hoboken). 2010; 62(4):473-479.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Siebel T., Kelm J., Porsch M., Regitz T., Neumann W.H. Two-stage exchange of infected knee arthroplasty with an prosthesis-like interim cement spacer. Acta Orthop Belg. 2002; 68:150-156.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Sonohata M., Kitajima M., Kawano S., Mawatari M. Acute hematogenous infection of revision total hip arthroplasty by oral bacteria in a patient without a history of dental procedures: case report. Open Orthop J. 2014; 8:56-59. doi: 10.2174/1874325001408010056.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Spangehl M.J., Masri B.A., O’Connell J.X. Prospective analysis of preoperative and intraoperative investigations for diagnosis of infection at the sites of two hundred and two revision total hip arthroplasty. J Bone Joint Surg Am. 1999; 81(5): 672-683.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Squire M.W., Della Valle C.J., Parvizi J. Preoperative diagnosis of periprosthetic joint infection: Role of aspiration. AJR. 2011; 196:875-879.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Tsukayama D.T., Estrada R., Gustilo R.B. Infection after total hip arthroplasty: a study of the treatment of one hundred and six infections. J Bone Joint Surg Am. 1996; 78(4):512-523.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Waldman B.J., Hostin E., Mont M.A., Hunfergord D.S. Infected total knee arthroplasty treated by arthroscopic irrigation and debridement. J Arthropl. 2000; 15: 430-436.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Wu C., Qu X., Liu F., Li H., Mao Y., Zhu Z. Risk factors for periprosthetic joint infection after total hip arthroplasty and total knee arthroplasty in Chinese patients. PLoS One. 2014; 9(4):e95300. doi: 10.1371/journal.pone.0095300.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Zimmerli W., Trampuz A. Ochsner P.E. Prosthetic joint infections. NEJM. 2004; 351:1645-1654.</mixed-citation></ref></ref-list></back></article>
