ALLOGENEIC BONE GRAFTING MATERIALS – UPDATE OF THE CURRENT SCIENTIFIC STATUS

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Abstract

Worldwide population aging and associated with it epidemics of osteoporosis, widespread of bone and joint reconstructive surgery and first of all joint replacement lead to explosive growth of interest in bone grafting.

Although autografts are still the golden standard in bone regeneration, allogeneic bone substitutes have reached a state that allows for their application with satisfying clinical results. However, it has repeatedly been supposed that the different allogeneic materials underwent different purification processes, which modifies bone regeneration properties of these materials and also for different safety conditions. In the present publication, the treatment of the precursor tissue, the safety conditions, and the regenerative possibilities of C+TBA bone blocks based in preclinical and clinical data are described. Thus, it is described how the risks of infections and also immunological reactions becomes completely eliminated, while the special purification process allows for preservation of the native structure of the bone block. Both the in vitro studies and the clinical trials including histological follow-ups showed the optimal regeneration properties of these bone blocks. It has been shown that the allogeneic bone grafts have been integrated without causing inflammatory anomalies at the implantation site. Altogether, the allogeneic bone substitute material serves as an excellent basis for the formation of new bone. Finally, the combination of the allogeneic C+TBA bone blocks with different antibiotics is described. Interestingly, it is possible to combine the allogeneic bone substitute ether with antibiotics in the sense of prophylaxis and/or with bone marrow aspirate in order to accelerate bone remodeling.

About the authors

R. Schnettler

University Medical Center, Justus Liebig University of Giessen

Author for correspondence.
Email: Reinhard.Schnettler@chiru.med.uni-giessen.de

Reinhard Schnettler — MD, professor, the Head of the Trauma Surgery Department.

Klinikstrasse, 29, D-35392 Giessen

Germany

J. Franke

Elbe Klinikum

Email: fake@neicon.ru

Jorg Franke — MD, the Head of the Department of Trauma and Orthopaedic Surgery, Elbe Klinikum Stade Unfallchirurgie und Orthopädie.

Stade Germany

D. Rimashevskiy

Peoples› Friendship University of Russia

Email: fake@neicon.ru

Dmitry Rimashevskiy — Cand. Sci. (Med.) Associate Professor, Traumatology and Orthopedics Department.

Moscow

Russian Federation

N. Zagorodniy

Peoples› Friendship University of Russia

Email: fake@neicon.ru

MoscowNikolai V. Zagorodniy — Dr. Sci. (Med.), professor, the Head of Traumatology and Orthopedics Department.

Moscow Russian Federation

N. Batpenov

Scientific Research Institute of Traumatology and Orthopedics

Email: fake@neicon.ru

Nurlan Batpenov — MD, Dr. Sci. (Med.), professor, director.

Astana Kazakhstan

R. E. Unger

Institute of Pathology, Johannes Gutenberg University

Email: fake@neicon.ru

Ronald E. Unger — MD.

Mainz Germany

S. Wenisch

Institute of Veterinary Anatomy, Histology and Embryology, Justus Liebig University of Giessen

Email: fake@neicon.ru

Sabina Wenisch — MD, Professor.

Giessen

Germany

M. Barbeck

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin; Botiss Biomaterials

Email: fake@neicon.ru

Mike Barbeck — MD, Senior Researcher.

Berlin Germany

References

  1. Finkemeier C.G. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am. 2002;84-A(3):454-464.
  2. Giannoudis P.V., Dinopoulos H., Tsiridis E. Bone substitutes: an update. Injury. 2005;36 Suppl 3:20-27.
  3. Kurz L.T., Garfin S.R., Booth R.E. Jr. Harvesting autogenous iliac bone grafts: a review of complications and techniques. Spine (Phila Pa 1976). 1989;14(12):1324-1331.
  4. Dimitriou R., Mataliotakis G.I., Angoules A.G., Kanakaris N.K., Giannoudis P.V. Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury. 2011;42 Suppl 2:3-15. doi: 10.1016/j.injury.2011.06.015.
  5. Laurencin C., Khan Y., El-Amin S.F. Bone graft substitutes. Expert Rev Med Devices. 2006;3(1):49-57.
  6. Schmitt C.M., Doering H., Schmidt T., Lutz R., Neukam F.W., Schlegel K.A. Histological results after maxillary sinus augmentation with Straumann® BoneCeramic, Bio-Oss®, Puros®, and autologous bone. A randomized controlled clinical trial. Clin Oral Implants Res. 2013;24(5):576-585. doi: 10.1111/j.1600-0501.2012.02431.x.
  7. Damien C.J., Parsons J.R. Bone graft and bone graft substitutes: a review of current technology and applications. J Appl Biomater. 1991;2(3):187-208.
  8. Malinin T., Temple H.T. Comparison of frozen and freeze-dried particulate bone allografts. Cryobiology. 2007;55(2):167-170. doi: 10.1016/j.cryobiol.2007.05.007.
  9. Simpson D., Kakarala G., Hampson K., Steele N., Ashton B. Viable cells survive in fresh frozen human bone allografts. Acta Orthop. 2007;78(1):26-30. doi: 10.1080/17453670610013385.
  10. Borghetti A., Novakovitch G., Louise F., Simeone D., Fourel J. Cryopreserved cancellous bone allograft in periodontal intraosseous defects. J Periodontol. 1993;64(2):128-132. doi: 10.1902/jop.1993.64.2.128.
  11. Schoepf Ch. The Tutoplast® Process: a review of efficacy. Zimmer Dental. 2008;17:40-50.
  12. Pruss A., Göbel U.B., Pauli G., Kao M., Seibold M., Mönig H.J., Hansen A., von Versen R. Peracetic acidethanol treatment of allogeneic avital bone tissue transplants--a reliable sterilization method. Ann Transplant. 2003;8(2):34-42.
  13. Osbon D.B., Lilly G.E., Thompson C.W., Jost T. Bone grafts with surface decalcified allogeneic and particulate autologous bone: report of cases. J Oral Surg. 1977;35(4):276-284.
  14. Lee D.W., Pi S.H., Lee S.K., Kim E.C. Comparative histomorphometric analysis of extraction sockets healing implanted with bovine xenografts, irradiated cancellous allografts, and solvent-dehydrated allografts in humans. Int J Oral Maxillofac Implants. 2009;24(4):609-615.
  15. Mellonig J.T. Freeze-dried bone allografts in periodontal reconstructive surgery. Dent Clin North Am. 1991;35(3):505-520.
  16. Beck T.M., Mealey B.L. Histologic analysis of healing after tooth extraction with ridge preservation using mineralized human bone allograft. J Periodontol. 2010;81(12):1765-1772. doi: 10.1902/jop.2010.100286.
  17. Kluger R., Bouhon W., Freudenberger H., Kröner A., Engel A., Hoffmann O. Removal of the surface layers of human cortical bone allografts restores in vitro osteoclast function reduced by processing and frozen storage. Bone. 2003;32(3):291-296.
  18. Asselmeier M.A., Caspari R.B., Bottenfield S. A review of allograft processing and sterilization techniques and their role in transmission of the human immunodeficiency virus. Am J Sports Med. 1993;21(2):170-175. doi: 10.1177/036354659302100202.
  19. Linley E., Denyer S.P., McDonnell G., Simons C., Maillard J.Y. Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. J Antimicrob Chemother. 2012;67(7):1589-1596. doi: 10.1093/jac/dks129.
  20. Singh R., Singh D., Singh A. Radiation sterilization of tissue allografts: A review. World J Radiol. 2016;8(4):355-369. doi: 10.4329/wjr.v8.i4.355.
  21. Tomford W.W. Transmission of disease through transplantation of musculoskeletal allografts. J Bone Joint Surg Am. 1995;77(11):1742-1754.
  22. Hinsenkamp M., Muylle L., Eastlund T., Fehily D., Noël L., Strong D.M. Adverse reactions and events related to musculoskeletal allografts: reviewed by the World Health Organisation Project NOTIFY. Int Orthop. 2012;36(3):633-641. doi: 10.1007/s00264-011-1391-7.
  23. Grover V., Kapoor A., Malhotra R., Sachdeva S. Bone allografts: a review of safety and efficacy. Indian J Dent Res. 2011;22(3):496. doi: 10.4103/0970-9290.87084.
  24. Buck B.E., Malinin T.I., Brown M.D. Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS). Clin Orthop Relat Res. 1989;(240):129-136.
  25. Conrad E.U., Gretch D.R., Obermeyer K.R., Moogk M.S., Sayers M., Wilson J.J., Strong D.M. Transmission of the hepatitis-C virus by tissue transplantation. J Bone Joint Surg Am. 1995;77(2):214-224.
  26. O’Sullivan E.D., Battle R.K., Zahra S., Keating J.F., Marson L.P., Turner D.M. Allosensitization Following Bone Graft. Am J Transplant. 2017;17(8):2207-2211. doi: 10.1111/ajt.14231.
  27. Piaia M., Bub C.B., Succi G.M., Torres M., Costa T.H., Pinheiro F.C., Napimoga M.H. HLA-typing analysis following allogeneic bone grafting for sinus lifting. Cell Tissue Bank. 2017;18(1):75-81. doi: 10.1007/s10561-016-9594-1.
  28. Mosconi G., Baraldi O., Fantinati C., Panicali L., Veronesi M., Cappuccilli M.L. et al. Donor-specific antiHLA antibodies after bone-graft transplantation. Impact on a subsequent renal transplantation: a case report. Transplant Proc. 2009;41(4):1138-1141. doi: 10.1016/j.transproceed.2009.02.059.
  29. Friedlaender G.E., Strong D.M., Sell K.W. Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts. J Bone Joint Surg Am. 1984;66(1):107-112.
  30. Ward W.G., Gautreaux M.D., Lippert D.C. 2nd, Boles C. HLA sensitization and allograft bone graft incorporation. Clin Orthop Relat Res. 2008;466(8):1837-1848. doi: 10.1007/s11999-008-0294-4.
  31. Quattlebaum J.B., Mellonig J.T., Hensel N.F. Antigenicity of freeze-dried cortical bone allograft in human periodontal osseous defects. J Periodontol. 1988;59(6):394-397.
  32. Reikerås O., Reinholt F.P., Zinöcker S., Shegarfi H., Rolstad B. Healing of long-term frozen orthotopic bone allografts is not affected by MHC differences between donor and recipient. Clin Orthop Relat Res. 2011;469(5): 1479-1486. doi: 10.1007/s11999-011-1796-z.
  33. Fretwurst T., Spanou A., Nelson K., Wein M., Steinberg T., Stricker A. Comparisonof four different allogeneic bone grafts for alveolar ridge reconstruction: a preliminary histologic and biochemical analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(4):424-431. doi: 10.1016/j.oooo.2014.05.020.
  34. Lorenz J., Schlee M., Al-Maawi S., Chia P., Sader R.A., Ghanaati S. Variant Purification of an Allogeneic Bone Block. Acta Stomatol Croat. 2017;51(2):141-147. doi: 10.15644/asc51/2/7.
  35. Klemm K.W. Gentamicin-PMMA chains (Septopal chains) for the local antibiotic treatment of chronic osteomyelitis. Reconstr Surg Traumatol. 1988;20:11-35.
  36. Alt V., Bitschnau A., Böhner F., Heerich K.E., Magesin E., Sewing A. et al. Effects of gentamicin and gentamicin–RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: An experimental study in rabbits. Acta Biomater. 2011;7(3):1274-1280. doi: 10.1016/j.actbio.2010.11.012.
  37. Heppert V., Wagner Ch., Glatzel U., Wentzensen A. Prinzipien der operative-chirurgischen Therapie der Osteitis. Trauma Berufskrankh. 2002:4(3):321-328. (in German).
  38. Luther C., Unger K., Heppert V., Simon R., Hitzigrath C., Germann G., Sauerbier M. [Chronic osteitis of the lower extremities. An interdisciplinary treatment concept]. Unfallchirurg. 2010;113(5):386-393. (in German). doi: 10.1007/s00113-009-1709-8.

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