IMPLANT-ASSOCIATED PATHOLOGY: AN ALGORITHM FOR IDENTIFYING PARTICLES IN HISTOPATHOLOGIC SYNOVIALIS/SLIM DIAGNOSTICS

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Abstract

In histopathologic SLIM diagnostic (synovial-like interface membrane, SLIM) apart from diagnosing periprosthetic infection particle identification has an important role to play. The differences in particle pathogenesis and variability of materials in endoprosthetics explain the particle heterogeneity that hampers the diagnostic identification of particles. For this reason, a histopathological particle algorithm has been developed. With minimal methodical complexity this histopathological particle algorithm offers a guide to prosthesis material-particle identification. Light microscopic-morphological as well as enzyme-histochemical characteristics and polarization-optical proporties have set and particles are defined by size (microparticles, macroparticles and supra- macroparticles) and definitely characterized in accordance with a dichotomous principle. Based on these criteria, identification and validation of the particles was carried out in 120 joint endoprosthesis pathological cases. A histopathological particle score (HPS) is proposed that summarizes the most important information for the orthopedist, material scientist and histopathologist concerning particle identification in the SLIM.

About the authors

V. Krenn

Center for Histology, Cytology and Molecular Diagnostics

Author for correspondence.
Email: krenn@patho-trier.de
Russian Federation

P. Thomas

Hospital and Outpatients’ Clinic for Dermatology and Allergology, Ludwig Maximilian University

Email: noemail@neicon.ru
Russian Federation

M. Thomsen

DRK Hospital, Orthopedics and Trauma Surgery

Email: noemail@neicon.ru
Russian Federation

S. Usbeck

CeramTec GmbH

Email: noemail@neicon.ru
Russian Federation

L. Scheuber

CeramTec GmbH

Email: noemail@neicon.ru
Russian Federation

F. Boettner

Hospital for Special Surgery/HSS

Email: noemail@neicon.ru
Russian Federation

W. Rüther

University Medical Center Hamburg Eppendorf

Email: noemail@neicon.ru
Russian Federation

F. Hopf

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
Russian Federation

S. Müller

Center for Histology, Cytology and Molecular Diagnostics

Email: noemail@neicon.ru
Russian Federation

M. G. Krukemeyer

Paracelsus-Kliniken Deutschland Gmbh

Email: noemail@neicon.ru
Russian Federation

T. Gehrke

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
Russian Federation

D. Kendoff

HELIOS ENDO-Klinik

Email: noemail@neicon.ru
Russian Federation

A. Tiemann

SRH Zentralklinikum Suhl, Klinik für Orthopädie und Unfallchirurgie

Email: noemail@neicon.ru
Russian Federation

M. Huber

Institute of Pathology and Bacteriology, Otto Wagner Hospital

Email: noemail@neicon.ru
Russian Federation

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