FEATURES OF IMMUNE STATUS IN ADOLESCENTS WITH COXARTHROSIS

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Abstract

Purpose: To Study immune status in patients with coxarthrosis consequent to treatment of congenital hip dysplasia and Perthes' disease as well as to determine additional variables indicating arthrosis progression.

Materials and methods: The authors analyzed results of preoperative immune examination of 13 male patients aged 11,4±0,7 years (10-13) with coxarthrosis of type I-II developed consequently to treatment of hip dysplasia and Perthes' disease. Based on obtained anatomical and functional outcomes the authors divided the patients into two groups. First group included 8 patients with postoperative improvement of joint function and absence of disease progression. Second group (5 patients) was featured by functional deterioration and arthrosis advancing.

Results: Patients of the second group demonstrated statistically significant elevation in certain parameters of humoral (circulating immune complex) and cellular immunity (CD3+HLA-DR (%), CD3+HLA-DR (109/l)) as well as interleukin-6.

Conclusion: Obtained results have proven that initial immune parameters (IL-6, circulating immune complex, lymphocytes with activation markers) can be used as additional variables for decision making in regard to option and advisability of reconstructive joint preserving procedures in patients with coxarthrosis consequent to treatment of hip dysplasia and Perthes' disease.

About the authors

M. V. Chepeleva

Ilizarov Russian Scientific Center «Restorative Traumatology and Orthopedics», Kurgan

Email: fake@neicon.ru

Chepeleva Marina V. - senior researcher, laboratory of clinical microbiology and immunology

Russian Federation

M. P. Teplenky

Ilizarov Russian Scientific Center «Restorative Traumatology and Orthopedics», Kurgan

Author for correspondence.
Email: TeplenkiyMp@mail.ru

Teplenky Mikhail P. - head of the laboratory of pathology of the join.

Ul. M. Ulyanova, 6, Kurgan, Russia, 640014, e-mail: TeplenkiyMP@mail.ru

Russian Federation

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