Improvement of Perioperative Management of Patients Undergoing Surgical Treatment for Hip Periprosthetic Joint Infection

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Abstract

Two-stage revision arthroplasty in chronic hip periprosthetic joint infection cases is the “gold standard” treatment. First stage debridement leads to large intraoperative and drainage blood loss using standard protocols for thromboprophylaxis and drainage of the surgical wound, which is a significant disadvantage of perioperative management of such patients.

The aim of the study was to determine the effect of modified management protocol with delayed start of thromboprophylaxis and a short period of drainage on the blood loss and the effectiveness of debridement with antibiotic-impregnated spacer placement in patients with hip periprosthetic joint infection.

Materials and Methods. A single-center prospective study was conducted. 90 patients underwent endoprosthesis components removal and antibiotic-impregnated spacer placement. Patients were divided into 3 groups: start of thromboprophylaxis before surgery and 3–4 days of drainage; start of thromboprophylaxis no earlier than 12 hours after surgery and 3–4 days of drainage; start of thromboprophylaxis no earlier than 12 hours after surgery and 1 day of drainage.

Results. There was a statistically significant (p<0.05) decrease of drainage and total blood loss, and transfused blood volume in cases with the delayed start of thromboprophylaxis and a short period of drainage. The proposed protocol was safe for prevention of venous thromboembolic complications and did not affect the frequency of periprosthetic hip joint infection recurrence. The effectiveness of the first stage of treatment — 89%, the second stage — 99% in 1 year after rehabilitation according to the second international consensus on musculoskeletal infection criteria.

Conclusion. The modified protocol of perioperative management is an effective and safe as a blood-saving strategy and can be proposed for widespread use.

About the authors

A. A. Kochish

Vreden National Medical Research Center of Traumatology and Orthopedics

Author for correspondence.
Email: kochishman@gmail.com
ORCID iD: 0000-0001-8573-1096

Andrei A. Kochish — Orthopaedic Surgeon

St. Petersburg

Russian Federation

S. A. Bozhkova

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: clinpharm-rniito@yandex.ru
ORCID iD: 0000-0002-2083-2424

Svetlana A. Bozhkova — Dr. Sci. (Med.), Head of the research department of wound infection prevention and treatment

St. Petersburg

Russian Federation

V. A. Artyukh

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: artyukhva@mail.ru
ORCID iD: 0000-0002-5087-6081

Vasilii A. Artyukh — Cand. Sci. (Med.), Head of septic surgery department

St. Petersburg

Russian Federation

V. N. Liventsov

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: vnliventsov@yandex.ru
ORCID iD: 0000-0001-8748-2134

Vitaly N. Liventsov — Deputy Head of clinic for medical part

St. Petersburg

Russian Federation

A. V. Afanas’ev

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: avafanasev@rniito.ru
ORCID iD: 0000-0002-3097-7846

Alexander V. Afanas’ev — Orthopaedic Surgeon

St. Petersburg

Russian Federation

S. S. Toropov

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: doctoropovss@yandex.ru
ORCID iD: 0000-0002-9451-1834

Sergei S. Toropov — Orthopaedic Surgeon

St. Petersburg

Russian Federation

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