BONE AND SOFT TISSUES INTEGRATION IN POROUS TITANIUM IMPLANTS (EXPERIMENTAL RESEARCH)

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Abstract

Aim. It’s common that revision arthroplasty of the large joints demands replacing of bone defects of irregular geometrical shapes and simultaneous restoring of support ability and ability to integrate surrounding muscular and tendinous structures into an implant that is required for a complete restoration of joint function.

The purpose. To experimentally study the process of integration for muscular and bone tissue as well as tendinous and ligamentous structures into porous titanium materials.

Material and methods. During in vivo experiment the authors created a standardized bone defect in 6 rabbits of chinchilla breed at the point of patella ligament attachment as well as a delamination area of muscular tissue in latissimus dorsi. Both knee joints and both latissimus dorsi were used in each animal. Study group included titanium implants with three-dimensional mesh structure. Control group — solid titanium implants with standard porosity. Titanium implants were produced by additive technologies with preliminary prototyping. The porosity corresponded to trabecular metal, striations — 0.45, pores size —100–200 microns. Study and control components were implanted in the identical conditions into the corresponding anatomical sites. Postoperative AP and lateral roentgenograms of knee joints were performed for all animals. Morphological research was conducted on day 60 after the implantation and strength properties were studied at day 90 after the implantation.

Results. The authors observed bony ingrowth into implant pores with minimal volume of fibrous tissue, a distinct connective integration was reported represented by a dense fibrous tissue in the pores of components implanted into the muscular tissue. Testing of fixation strength of the study implants demonstrated a clearly superior strength of soft and bone tissue integration into the experimental mesh implants produced using additive technologies.

About the authors

R. M. Tikhilov

Vreden Russian Research Institute of Traumatology and Orthopedics; Mechnikov North-Western State Medical University.

Author for correspondence.
Email: fake@neicon.ru

Rashid M. Tikhilov — Dr. Sci. (Med.), professor, director; professor of Traumatology and Orthopedics.

Department

8, ul. Akad. Baykova, 195427, St. Petersburg; 41, Kirochnaya ul., 191015, St. Petersburg.

Russian Federation

I. I. Shubnyakov

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Igor I. Shubnyakov — Dr. Sci. (Med.), chief researcher.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

A. O. Denisov

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Alexei O. Denisov – Cand. Sci. (Med), academic secretary.
 
8, ul. Akad. Baykova, 195427, St. Petersburg. Russian Federation

V. A. Konev

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Vladimir A. Konev — Cand. Sci. (Med.), researcher, Research Department of Experimental Morphology.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

I. V. Gofman

Institute of macromolecular compounds, Russian academy of sciences.

Email: fake@neicon.ru

Iosif V. Gofman — Cand. Sci. (Chem.), senior researcher, Laboratory of Polymers and Composite Materials Mechanics.

31, Bol’shoi pr., 199004, St. Petersburg.

Russian Federation

P. M. Mikhailova

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: mihaylova_pm@mail.ru

Polina M. Mikhailova — researcher, Research Department of Hip Pathology.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

G. I. Netylko

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Georgy I. Netylko — head of the Research Department of Experimental Morphology.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

A. V. Vasiliev

Medical Genetics Research Center.

Email: fake@neicon.ru

Andrej V. Vasil’ev – Cand. Sci. (Med.), senior researcher, Laboratory of Stem Cell Genetics.

1, ul. Moskvorech’e, 115522, Moscow.

Russian Federation

L. O. Anisimova

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Larisa O. Anisimova — senior researcher, Research Department of Experimental Morphology.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

S. S. Bilyk

Vreden Russian Research Institute of Traumatology and Orthopedics.

Email: fake@neicon.ru

Stanislav S. Bilyk — researcher, Research Department of Hip Pathology.

8, ul. Akad. Baykova, 195427, St. Petersburg.

Russian Federation

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